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Titolo:
Expression of cytokines and inducible nitric oxide synthase in inflamed gingival tissue
Autore:
Hirose, M; Ishihara, K; Saito, A; Nakagawa, T; Yamada, S; Okuda, K;
Indirizzi:
Tokyo Dent Coll, Ctr Oral Hlth Res, Dept Periodont, Mihama Ku, Chiba 2618502, Japan Tokyo Dent Coll Chiba Japan 2618502 ont, Mihama Ku, Chiba 2618502, Japan Tokyo Dent Coll, Ctr Oral Hlth Res, Dept Microbiol, Mihama Ku, Chiba 2618502, Japan Tokyo Dent Coll Chiba Japan 2618502 iol, Mihama Ku, Chiba 2618502, Japan
Titolo Testata:
JOURNAL OF PERIODONTOLOGY
fascicolo: 5, volume: 72, anno: 2001,
pagine: 590 - 597
SICI:
0022-3492(200105)72:5<590:EOCAIN>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HUMAN POLYMORPHONUCLEAR LEUKOCYTES; POLYMERASE CHAIN-REACTION; ORAL PLAQUE SAMPLES; PERIODONTAL-DISEASE; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; PORPHYROMONAS-GINGIVALIS; ADULT PERIODONTITIS; CREVICULAR FLUID; TNF-ALPHA;
Keywords:
Actinobacillus actinomycetemcomitans; Porphyromonas gingivalis; periodontal diseases/microbiology; cytokines; nitric oxide synthase; polymerase chain reaction; reverse transcription;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Hirose, M Tokyo Dent Coll, Ctr Oral Hlth Res, Dept Periodont, Mihama Ku, 1-2-2 Masago, Chiba 2618502, Japan Tokyo Dent Coll 1-2-2 Masago Chiba Japan2618502 2618502, Japan
Citazione:
M. Hirose et al., "Expression of cytokines and inducible nitric oxide synthase in inflamed gingival tissue", J PERIODONT, 72(5), 2001, pp. 590-597

Abstract

Background: Periodontopathic bacteria induce inflammation of periodontal tissues. The cytokines and nitric oxide released in periodontal lesions havebeen reported to play a protective role in bacterial infection and to relate to the process of inflammation. To clarify the relationship between colonization of periodontopathic bacteria and cytokines, we evaluated profiles of inflammatory cytokines, chemokine, anti-inflammatory cytokines, and inducible nitric oxide synthase (iNOS) and colonization by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans, which are major pathogens ofperiodontitis. Methods: mRNA expression of cytokines and iNOS in inflamed and healthy gingival tissue was determined using reverse transcription-polymerase chain reaction (RT-PCR), and the relationship between their profiles and the detection of specific bacteria was analyzed. Results: The relative expression of interleukin (IL)-6 and iNOS mRNAs in periodontal lesions was significantly higher than those in healthy individuals. IL-6 mRNA expression was also significantly higher at bleeding on probing (BOP)-positive sites than at BOP-negative sites. The expressions of IL-1alpha and IL-8 increased, but IL-IO expression decreased at sites where A.actinomycetemcomitans was detected. We found no correlation between the expression of cytokine and iNOS mRNA and infection by P. gingivalis. Conclusions: The expression of IL-6 may reflect inflammation in gingival tissue, and iNOS may be involved in the inflammatory process in periodontitis. The presence of A. actinomycetemcomitans or P. gingivalis might relate to the different cytokine profiles of IL-1 alpha, IL-8, and IL-10.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:09:25