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Titolo:
Higher serum eosinophil cationic protein levels in children with cow's milk allergy
Autore:
Hidvegi, E; Cserhati, E; Kereki, E; Arato, A;
Indirizzi:
Semmelweis Univ Med, Dept Pediat 1, H-1083 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1083 1, H-1083 Budapest, Hungary Svabhegy Childrens Hosp, Budapest, Hungary Svabhegy Childrens Hosp Budapest Hungary ldrens Hosp, Budapest, Hungary
Titolo Testata:
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
fascicolo: 4, volume: 32, anno: 2001,
pagine: 475 - 479
SICI:
0277-2116(200104)32:4<475:HSECPL>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRANULE PROTEINS; FOOD ALLERGY; DISEASE; INFLAMMATION; INFANTS; MARKERS; RELEASE; ASTHMA;
Keywords:
allergy; child; cow's milk; eosinophil cationic protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Arato, A Semmelweis Univ Med, Dept Pediat 1, Bokay Janos U 53, H-1083 Budapest, Hungary Semmelweis Univ Med Bokay Janos U 53 Budapest Hungary H-1083ary
Citazione:
E. Hidvegi et al., "Higher serum eosinophil cationic protein levels in children with cow's milk allergy", J PED GASTR, 32(4), 2001, pp. 475-479

Abstract

Background: In the pathogenesis of cow's milk allergy, abnormal immunologically mediated reactions play a basic role. Eosinophil activation also participates in the development of several allergies. The purpose of this studywas to characterize the degree of this activation by measuring the serum level of eosinophil cationic protein (sECP) and establishing whether it is auseful parameter in monitoring oral cow's milk allergy. Methods: The sECP level of 35 patients with previously confirmed cow's milk allergy (mean age, 16 months) was evaluated using a fluoroimmunoassay before the cow's milk rechallenge test and at 2 hours and 24 hours after cow'smilk challenge. Results: Of the 35 children with previously confirmed cow's milk allergy, 10 had positive clinical reactions after the milk rechallenge test, whereas25 children had no reaction. The median sECP level of all the patients before the challenge test was significantly higher (12.4 mug/L) than that of the control group (4.3 mug/L) (P < 0.05). Two hours after the challenge, theme dian sECP of all patients (9.4 mug/L) was lower than the starting values. The median sECP levels were higher in children with positive challenge test results at all time points. However, this difference was not statistically significant. Conclusions: The normalization of sECP level may indicate the cessation ofthe cow's milk allergy. Therefore, the measurement of sECP may be helpful in determining the optimal time in which to repeat the challenge test, whenthe result will more likely be negative. The significant decrease of the sECP level 2 hours after the beginning of milk challenge test may be explained by the fact that this protein is excreted into the intestinal lumen.

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Documento generato il 30/09/20 alle ore 07:56:24