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Titolo:
Disease-associated autoantibodies as predictive markers of type 1 diabetesmellitus in siblings of affected children
Autore:
Kimpimaki, T; Knip, M;
Indirizzi:
Univ Helsinki, Hosp Children & Adolescents, FIN-00029 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00029 ts, FIN-00029 Helsinki, Finland Tampere Univ, Sch Med, Dept Pediat, Helsinki, Finland Tampere Univ Helsinki Finland , Sch Med, Dept Pediat, Helsinki, Finland Tampere Univ Hosp, Helsinki, Finland Tampere Univ Hosp Helsinki FinlandTampere Univ Hosp, Helsinki, Finland
Titolo Testata:
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
, volume: 14, anno: 2001, supplemento:, 1
pagine: 575 - 587
SICI:
0334-018X(200106)14:<575:DAAPMO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISLET-CELL-ANTIBODIES; FIRST-DEGREE RELATIVES; GLUTAMIC-ACID DECARBOXYLASE; INSULIN AUTOANTIBODIES; GENETIC RISK; HLA MARKERS; GENERAL-POPULATION; POSITIVE SIBLINGS; EARLY EXPRESSION; GERMAN BABYDIAB;
Keywords:
type 1 diabetes mellitus; autoantibodies; HLA risk markers; predictive markers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Knip, M Univ Helsinki, Hosp Children & Adolescents, POB 281, FIN-00029 Helsinki, Finland Univ Helsinki POB 281 Helsinki Finland FIN-00029 elsinki, Finland
Citazione:
T. Kimpimaki e M. Knip, "Disease-associated autoantibodies as predictive markers of type 1 diabetesmellitus in siblings of affected children", J PED END M, 14, 2001, pp. 575-587

Abstract

The long latent preclinical period of type 1 diabetes mellitus (DM) makes it possible to identify individuals at increased risk for clinical DM before the beta -cell destructive process has reached the point of no return. A series of reports on the predictive value of DM-associated autoantibodies are available in first-degree relatives of patients with type 1 DM, but onlya few of these studies target exclusively siblings and young siblings of affected children. When planning screening of siblings for DM risk, their age needs to be considered, as predictive characteristics of autoantibodies seem to vary in different age groups. Autoimmunity may be initiated early inlife and therefore early screening for signs of beta -cell autoimmunity iscrucial to avoid missing young children en route to overt DM and to be able to start intervention, when clinically applicable preventive modalities become available, before the disease process has advanced too far. Young age, positivity for at least two autoantibodies, high levels of autoantibodiesand low first phase insulin response are highly predictive for progressionto clinical disease in initially unaffected siblings of children with type1 DM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:32:59