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Titolo:
Autonomic innervation of tendons, ligaments and joint capsules. A morphologic and quantitative study in the rat
Autore:
Ackermann, PW; Li, J; Finn, A; Ahmed, M; Kreicbergs, A;
Indirizzi:
Karolinska Hosp, Karolinska Inst, Orthoped Lab, Dept Surg Sci, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Sci, S-17176 Stockholm, Sweden Karolinska Inst, Peptide Lab, Dept Surg Sci, Stockholm, Sweden Karolinska Inst Stockholm Sweden Lab, Dept Surg Sci, Stockholm, Sweden Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden Karolinska Inst Stockholm Sweden Dept Publ Hlth Sci, Stockholm, Sweden Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden Karolinska Inst Stockholm Sweden Physiol & Pharmacol, Stockholm, Sweden
Titolo Testata:
JOURNAL OF ORTHOPAEDIC RESEARCH
fascicolo: 3, volume: 19, anno: 2001,
pagine: 372 - 378
SICI:
0736-0266(200105)19:3<372:AIOTLA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; RABBIT KNEE-JOINT; NEUROPEPTIDE-Y; NERVE-FIBERS; SYMPATHETIC EFFERENTS; TYROSINE-HYDROXYLASE; RADIOIMMUNOASSAY; TISSUE; PAIN; IMMUNOREACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ackermann, PW Karolinska Hosp, Karolinska Inst, Orthoped Lab, Dept Surg Sci, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Stockholm, Sweden
Citazione:
P.W. Ackermann et al., "Autonomic innervation of tendons, ligaments and joint capsules. A morphologic and quantitative study in the rat", J ORTHOP R, 19(3), 2001, pp. 372-378

Abstract

We analyzed the neuronal occurrence of autonomic transmitters; noradrenaline (NA), neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), in the Achilles tendon, medial and lateral collateral ligaments and knee joint capsule in the rat by immunohistochemistry (IHC). In addition, the tissue concentrations of the sympathetic neuropeptide, NPY, and the parasympathetic peptide, VIP, were determined by radioimmunoassay (RIA). IHC demonstrated nerve fibers containing sympathetic vasoconstrictors - NA and NPY- and the parasympathetic vasodilator, VIP, in all tissues. NPY- and NA-positive nerve fibers were predominantly observed in larger blood vessels, whereas, nerve fibers immunoreactive to VIP were found in smaller vessels. In many nerve fibers a co-localization of the transmitters was seen. RIA showed thatthe concentration of NPY compared to VIP was 15-times higher in ligaments and twice as high in tendons and capsules. The differences noted may reflect a difference in vulnerability to degenerative conditions. In pathologicalconditions, dysregulation of autonomic transmitters in hypovascularized tissues subjected to repetitive mechanical load may contribute to tissue hypoxia leading to degeneration and rupture of tendons and ligaments. (C) 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:22:28