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Titolo:
Differential sensorimotor processing of vestibulo-ocular signals during rotation and translation
Autore:
Angelaki, DE; Green, AM; Dickman, JD;
Indirizzi:
Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Neurobiol, St Louis, MO 63110 USA Cent Inst Deaf, Dept Res, St Louis, MO 63110 USA Cent Inst Deaf St Louis MO USA 63110 af, Dept Res, St Louis, MO 63110 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 11, volume: 21, anno: 2001,
pagine: 3968 - 3985
SICI:
0270-6474(20010601)21:11<3968:DSPOVS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INNERVATING OTOLITH ORGANS; BRAIN-STEM NEURONS; PREPOSITUS-HYPOGLOSSI NEURONS; HORIZONTAL EYE-MOVEMENT; LINEAR HEAD MOTION; SQUIRREL-MONKEY; ABDUCENS NUCLEUS; VIEWING DISTANCE; DISCHARGE PATTERNS; NEURAL INTEGRATOR;
Keywords:
eye movement; binocular; vestibular; vestibulo-ocular; modeling; otolith organs; sensorimotor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Angelaki, DE Washington Univ, Sch Med, Dept Anat & Neurobiol, Box 8108,660S Euclid Ave, St Louis, MO 63110 USA Washington Univ Box 8108,660 S EuclidAve St Louis MO USA 63110
Citazione:
D.E. Angelaki et al., "Differential sensorimotor processing of vestibulo-ocular signals during rotation and translation", J NEUROSC, 21(11), 2001, pp. 3968-3985

Abstract

Rotational and translational vestibulo-ocular reflexes (RVOR and TrVOR) function to maintain stable binocular fixation during head movements. Despitesimilar functional roles, differences in behavioral, neuroanatomical, and sensory afferent properties suggest that the sensorimotor processing may bepartially distinct for the RVOR and TrVOR. To investigate the currently poorly understood neural correlates for the TrVOR, the activities of eye movement-sensitive neurons in the rostral vestibular nuclei were examined during pure translation and rotation under both stable gaze and suppression conditions. Two main conclusions were made. First, the 0.5 Hz firing rates of cells that carry both sensory head movement and motor-like signals during rotation were more strongly related to the oculomotor output than to the vestibular sensory signal during translation. Second, neurons the firing rates of which increased for ipsilaterally versus contralaterally directed eye movements (eye-ipsi and eye-contra cells, respectively) exhibited distinct dynamic properties during TrVOR suppression. Eye-ipsi neurons demonstrated relatively flat dynamics that was similar to that of the majority of vestibular-only neurons. In contrast, eye-contra cells were characterized by low-pass filter dynamics relative to linear acceleration and lower sensitivities than eye-ipsi cells. In fact, the main secondary eye-contra neuron in the disynaptic RVOR pathways (position-vestibular-pause cell) that exhibits a robust modulation during RVOR suppression did not modulate during TrVOR suppression. To explain these results, a simple model is proposed that is consistent with the known neuroanatomy and postulates differential projections ofsensory canal and otolith signals onto eye-contra and eye-ipsi cells, respectively, within a shared premotor circuitry that generates the VORs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:31:07