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Titolo:
A common exocytotic mechanism mediates axonal and dendritic outgrowth
Autore:
Martinez-Arca, S; Coco, S; Mainguy, G; Schenk, U; Alberts, P; Bouille, P; Mezzina, M; Prochiantz, A; Matteoli, M; Louvard, D; Galli, T;
Indirizzi:
Inst Curie, CNRS, UMR 144, Sect Rech, F-75231 Paris 05, France Inst CurieParis France 05 UMR 144, Sect Rech, F-75231 Paris 05, France Inst Fer Moulin, INSERM, U536, F-75005 Paris, France Inst Fer Moulin Paris France F-75005 INSERM, U536, F-75005 Paris, France CNR, Ctr Synapt Dev & Funct, I-20129 Milan, Italy CNR Milan Italy I-20129 NR, Ctr Synapt Dev & Funct, I-20129 Milan, Italy CNR, Ctr Cellular & Mol Pharmacol, I-20129 Milan, Italy CNR Milan Italy I-20129 r Cellular & Mol Pharmacol, I-20129 Milan, Italy CNR, Bruno Ceccarelli Ctr, I-20129 Milan, Italy CNR Milan Italy I-20129CNR, Bruno Ceccarelli Ctr, I-20129 Milan, Italy Ecole Normale Super, CNRS, UMR 8542, F-75005 Paris, France Ecole Normale Super Paris France F-75005 UMR 8542, F-75005 Paris, France Inst Curie, CNRS, UMR 144, F-75005 Paris, France Inst Curie Paris FranceF-75005 ie, CNRS, UMR 144, F-75005 Paris, France CNRS, URA 1923, F-91002 Evry, France CNRS Evry France F-91002CNRS, URA 1923, F-91002 Evry, France
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 11, volume: 21, anno: 2001,
pagine: 3830 - 3838
SICI:
0270-6474(20010601)21:11<3830:ACEMMA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED HIPPOCAMPAL-NEURONS; NEURITE OUTGROWTH; MEMBRANE-PROTEIN; VESICULAR TRANSPORT; GENE-EXPRESSION; POLARITY; GROWTH; CELLS; FUSION; SNARE;
Keywords:
axonal outgrowth; dendritic outgrowth; exocytosis; SNARE; TI-VAMP; adeno-associated virus; neurons in primary culture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Galli, T Inst Curie, CNRS, UMR 144, Sect Rech, 26 Rue Ulm, F-75231 Paris 05, France Inst Curie 26 Rue Ulm Paris France 05 , F-75231 Paris 05, France
Citazione:
S. Martinez-Arca et al., "A common exocytotic mechanism mediates axonal and dendritic outgrowth", J NEUROSC, 21(11), 2001, pp. 3830-3838

Abstract

Outgrowth of the dendrites and the axon is the basis of the establishment of the neuronal shape, and it requires addition of new membrane to both growing processes. It is not yet clear whether one or two exocytotic pathways are responsible for the respective outgrowth of axons and dendrites. We have previously shown that tetanus neurotoxin-insensitive vesicle-associated membrane protein (TI-VAMP) defines a novel network of tubulovesicular structures present both at the leading edge of elongating dendrites and axons of immature hippocampal neurons developing in primary culture and that TI-VAMPis an essential protein for neurite outgrowth in PC12 cells. Here we show that the expression of the N-terminal domain of TI-VAMP inhibits the outgrowth of both dendrites and axons in neurons in primary culture. This effect is more prominent at the earliest stages of the development of neurons in vitro. Expression of the N-terminal domain deleted form of TI-VAMP has the opposite effect. This constitutively active form of TI-VAMP localizes as theendogenous protein, particularly concentrating at the leading edge of growing axons. Our results suggest that a common exocytotic mechanism that relies on TI-VAMP mediates both axonal and dendritic outgrowth in developing neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:42:41