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Titolo:
Membrane resonance and subthreshold membrane oscillations in mesencephalicV neurons: Participants in burst generation
Autore:
Wu, NP; Hsiao, CF; Chandler, SH;
Indirizzi:
Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 11, volume: 21, anno: 2001,
pagine: 3729 - 3739
SICI:
0270-6474(20010601)21:11<3729:MRASMO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE-SPINDLE AFFERENTS; PIG TRIGEMINAL MOTONEURONS; ROOT GANGLION NEURONS; INTRACELLULAR BIOTINAMIDE; POTENTIAL OSCILLATIONS; FREQUENCY PREFERENCES; NEOCORTICAL NEURONS; NEUROPATHIC PAIN; NERVE INJURY; IN-VITRO;
Keywords:
trigeminal mesencephalic neurons; resonance; subthreshold oscillations; oral-motor activity; 4-AP-sensitive current; TTX-sensitive persistent sodium current;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Chandler, SH Univ Calif Los Angeles, Dept Physiol Sci, 2851 Slichter Hall,Los Angeles,CA 90095 USA Univ Calif Los Angeles 2851 Slichter Hall Los Angeles CA USA 90095
Citazione:
N.P. Wu et al., "Membrane resonance and subthreshold membrane oscillations in mesencephalicV neurons: Participants in burst generation", J NEUROSC, 21(11), 2001, pp. 3729-3739

Abstract

Trigeminal mesencephalic (Mes V) neurons are critical components of the circuits controlling oral-motor activity. The possibility that they can function as interneurons necessitates a detailed understanding of the factors controlling their soma excitability. Using whole-cell patch-clamp recording, in vitro, we investigated the development of the ionic mechanisms responsible for the previously described subthreshold membrane oscillations and rhythmical burst discharge in Mes V neurons from rats ages postnatal day (P) 2-12. We found that the oscillation amplitude and frequency increased during development, whereas bursting emerged after P6. Furthermore, when bursting was initiated, the spike frequency was largely determined by the oscillation frequency. Frequency domain analysis indicated that these oscillations emerged from the voltage-dependent resonant properties of Mes V neurons. Low doses of 4-aminopyridine (<100 <mu>M) reduced the oscillations and abolished resonance in most neurons, suggesting that the resonant current is a steady-state K+ current (I4-AP). Sodium ion replacement or TTX reduced substantially the oscillations and peak amplitude of the resonance, suggesting the presence of a persistent Na+ current (I-NaP) that functions to amplify the resonance and facilitate the emergence of subthreshold oscillations and bursting.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 02:06:58