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Titolo:
Steroid-sensitive gene-1 is an androgen-regulated gene expressed in prostatic smooth muscle cells in vivo
Autore:
Marcantonio, D; Chalifour, LE; Alaoui-Jamali, MA; Huynh, HT;
Indirizzi:
McGill Univ, Sir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Dept Oncol, Montreal, PQ H3T 1E2, Canada McGill Univ Montreal PQ Canada H3T 1E2 ncol, Montreal, PQ H3T 1E2, Canada McGill Univ, Sir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Dept Med, Montreal, PQ H3T 1E2, Canada McGill Univ Montreal PQ Canada H3T 1E2 Med, Montreal, PQ H3T 1E2, Canada
Titolo Testata:
JOURNAL OF MOLECULAR ENDOCRINOLOGY
fascicolo: 3, volume: 26, anno: 2001,
pagine: 175 - 184
SICI:
0952-5041(200106)26:3<175:SGIAAG>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT VENTRAL PROSTATE; GROWTH-FACTOR SYSTEM; EPITHELIAL INTERACTIONS; ESTROGEN; CANCER; CASTRATION; 5-ALPHA-REDUCTASE; FINASTERIDE; HYPERPLASIA; INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Huynh, HT Natl Canc Ctr, Mol Endocrinol Lab, 11 Hosp Dr, Singapore 169610,Singapore Natl Canc Ctr 11 Hosp Dr Singapore Singapore 169610 , Singapore
Citazione:
D. Marcantonio et al., "Steroid-sensitive gene-1 is an androgen-regulated gene expressed in prostatic smooth muscle cells in vivo", J MOL ENDOC, 26(3), 2001, pp. 175-184

Abstract

Steroid-sensitive gene-1 (SSG1) is a novel gene ne cloned, found regulatedby 17 beta -estradiol in the rat uterus and mammary gland, and over-expressed in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors. We show here that SSG1 mRNA and protein expression are regulated by androgens in therat ventral prostate. Increases in SSG1 mRNA levels were detected bq: Northern blotting after 24 h and reached a 27-fold peak 96 h following castration, relative to SSG1 mRNA expression in sham-operated rats. Dihydrotestosterone or testosterone supplementation of castrated rats prevented this rise in SSG1 mRNA. In contrast with SSG1 mRNA expression, SSG1 protein was decreased 16-fold 2 weeks following castration but was at control levels in the prostates of castrated rats receiving dihydrotestosterone or testosterone. Although SSG1 is regulated by androgens in vivo, treatment of LnCap cells with dihydrotestosterone, cyproterone acetate or flutamide did not result inthe regulation of SSG1 protein levels in vitro. Immunofluorescence studiesshow that SSG1 is mainly expressed in prostatic smooth muscle cells. Theseresults indicate that SSG1 is an androgen-regulated gene that is expressedin the smooth muscle component of the rat ventral prostate in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 17:31:27