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Titolo:
A lipoprotein-containing particle is transferred from the serum across themammary epithelium into the milk of lactating mice
Autore:
Monks, J; Huey, PU; Hanson, L; Eckel, RH; Neville, MC; Gavigan, S;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Physiol & Biophys, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Physiol & Biophys, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Dept Med, Div Endocrinol Diabet & Metab, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 ol Diabet & Metab, Denver, CO 80262 USA
Titolo Testata:
JOURNAL OF LIPID RESEARCH
fascicolo: 5, volume: 42, anno: 2001,
pagine: 686 - 696
SICI:
0022-2275(200105)42:5<686:ALPITF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; MEDIATES SELECTIVE UPTAKE; FAT GLOBULE-MEMBRANE; RECEPTOR CLASS-B; SCAVENGER RECEPTOR; CHOLESTERYL ESTER; SR-BI; ANIONIC PHOSPHOLIPIDS; CD36; PROTEIN;
Keywords:
mammal gland; cholesterol; epithelium; LDL; LRLR-null mice; transcytosis; lipoprotein metabolism; milk secretion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Neville, MC Univ Colorado, Hlth Sci Ctr, Dept Physiol & Biophys, 4200 E 9th Ave, Denver, CO 80262 USA Univ Colorado 4200 E 9th Ave Denver CO USA 80262 CO 80262 USA
Citazione:
J. Monks et al., "A lipoprotein-containing particle is transferred from the serum across themammary epithelium into the milk of lactating mice", J LIPID RES, 42(5), 2001, pp. 686-696

Abstract

To investigate the role of low-density lipoprotein (LDL) in the delivery of cholesterol to the mammary gland during pregnancy and lactation, ive examined the distribution of radioactivity from I-125-tyramine cellobiose-LDL injected into the tail vein of female mice at various stages of the reproductive cycle, Changes in the proportion of isotope taken up by the mammary gland largely reflected the increased weight of the gland in pregnancy and lactation. In addition, during lactation, radioactivity tvas found in the milk and was associated with a protein of the molecular weight of apoB-100, Quantitatively similar results were obtained with mice homozygous for disruption of the LDL receptor gene (LDLR null). Analysis of endogenous lipoproteins showed that the milk lipoprotein particles were denser than the corresponding serum lipoproteins and largely depleted of triglyceride and cholesterol, Using fluorescence microscopy we visualize the sorting of apoB protein from the LDL lipid phase at the basal surface of the mammary epithelial cell of both wild-type and LDLR-null mice.j/r Our findings provide evidence that the mammary epithelium of the lactating mouse is able to take up LDL from the plasma by a non-LDLR-mediated process. An apoB-containing particle from which the cholesterol has been removed is transferred into milk.-Monks,J., P. U. Huey, L. Hanson, R. H. Eckel, M. C. Neville, and S. Gavigan. A lipoprotein-containing particle is transferred from the serum across the mammary epithelium into the milk of lactating mice,J.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 06:58:59