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Titolo:
Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes - a population-based study
Autore:
Bjorkegren, K; Svardsudd, K;
Indirizzi:
Uppsala Univ, Univ Uppsala Hosp, Dept Publ Hlth & Caring Sci, Family Med Sect, S-75185 Uppsala, Sweden Uppsala Univ Uppsala Sweden S-75185 ly Med Sect, S-75185 Uppsala, Sweden Skutskar Primary Hlth Care Ctr, Skutskar, Sweden Skutskar Primary Hlth Care Ctr Skutskar Sweden re Ctr, Skutskar, Sweden
Titolo Testata:
JOURNAL OF INTERNAL MEDICINE
fascicolo: 5, volume: 249, anno: 2001,
pagine: 423 - 432
SICI:
0954-6820(200105)249:5<423:SCFMAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA TOTAL HOMOCYSTEINE; NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; HORDALAND HOMOCYSTEINE; PSYCHOGERIATRIC POPULATION; REFERENCE INTERVALS; FOLIC-ACID; AGE 70; PEOPLE; SUPPLEMENTATION;
Keywords:
cobalamin; folate; homocysteine; methylmalonic acid; multivitamin; survey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Bjorkegren, K Uppsala Univ, Univ Uppsala Hosp, Dept Publ Hlth & Caring Sci, Family Med Sect, S-75185 Uppsala, Sweden Uppsala Univ Uppsala Sweden S-75185 -75185 Uppsala, Sweden
Citazione:
K. Bjorkegren e K. Svardsudd, "Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes - a population-based study", J INTERN M, 249(5), 2001, pp. 423-432

Abstract

Objectives. The possibilities of detecting tissue cobalamin and folate deficiency are under debate. In this report the levels of serum cobalamin, folate, methylmalonic acid (MMA) and total homocysteine (tHcy) and their interrelations in a representative random population sample are presented. Design. Cohort study. Setting. A general mid-Swedish population. Subjects. A 20% random sample of persons 70 years or older in a defined geographical area were invited to a survey. A total of 235 (85%) persons responded, out of whom 224 had no interfering diseases. Main outcome measures, Serum cobalamin, folate, MMA and tHcy. Results. The serum levels of cobalamin, folate, MMA and tHcy were all correlated to cobalamin and folic acid treatment. They were also correlated to the intake of multivitamin preparations. In addition, serum cobalamin was higher in untreated women than in men but not correlated to age. Serum folate was correlated neither to sex nor age. Serum tHcy and MMA were both directly correlated to age but MMA not to sex. MMA was inversely correlated to serum cobalamin but not to serum folate, whereas serum tHcy was inversely correlated to serum cobalamin, folate and creatinine. Neither serum cobalamin, folate, MMA nor tHcy had any significant correlation to haemoglobin, erythrocyte volume fraction (EVF) or mean red cell volume. Half of the study population had abnormal MMA or tHcy levels, suggesting a latent or overt tissue deficiency of cobalamin or folate. Conclusions. A substantial proportion of the elderly general population had signs of low tissue levels of cobalamin or folate, Amongst those who tookmultivitamin preparations this proportion was much lower.

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Documento generato il 05/04/20 alle ore 01:58:01