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Titolo:
Generation of cytotoxic T lymphocytes specific for human cytomegalovirus using dendritic cells in vitro
Autore:
Cho, HI; Han, H; Kim, CC; Kim, TG;
Indirizzi:
Catholic Univ Korea, Coll Med, Dept Microbiol & Immunol, Catholic Hematopoiet Stem Cell Transplantat Ctr, Seoul 137701, South Korea Catholic Univ Korea Seoul South Korea 137701 , Seoul 137701, South Korea
Titolo Testata:
JOURNAL OF IMMUNOTHERAPY
fascicolo: 3, volume: 24, anno: 2001,
pagine: 242 - 249
SICI:
1524-9557(200105/06)24:3<242:GOCTLS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLOGENEIC BONE-MARROW; NATURAL-KILLER-CELLS; IN-VITRO; ADOPTIVE TRANSFER; INFLUENZA-VIRUS; PROTEIN PP65; HUMAN BLOOD; RESPONSES; INFECTION; IMMUNITY;
Keywords:
human cytomegalovirus; dendritic cell; cytotoxic T lymphocytes; antigen presentation; immunotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, TG Catholic Univ Korea, Coll Med, Dept Microbiol & Immunol, Catholic Hematopoiet Stem Cell Transplantat Ctr, 505 Banpo Dong, Seoul 137701, SouthKorea Catholic Univ Korea 505 Banpo Dong Seoul South Korea 137701 Korea
Citazione:
H.I. Cho et al., "Generation of cytotoxic T lymphocytes specific for human cytomegalovirus using dendritic cells in vitro", J IMMUNOTH, 24(3), 2001, pp. 242-249

Abstract

For the adoptive immunotherapy in immunodeficient bone marrow transplant recipients to prevent and treat human cytomegalovirus (HCMV)-associated diseases, HCMV-pulsed dendritic cells (DCs) were used as antigen-presenting cells for the induction of cytotoxic T lymphocytes (CTLs) specific to HCMV antigens in vitro. The antiviral CTL responses induced by HCMV-pulsed DCs wereas highly efficient as those induced by HCMV-infected dermal fibroblasts, and endogenous viral gene expression was not required to induce virus-specific T-cell lines. The strong cytotoxic activity against HCMV-pp65, known asHCMV major antigen, was identified using autologous B lymphoblastoid cell line expressing pp65 antigen. The cytotoxic activity toward HCMV-infected target cells was found to be mediated primarily by CD8(+) T cells, although both CD8(+) cells and CD4(+) cells were able to lyse autologous virus-infected target cells. The CTLs contained a mixture of effector cells that recognized virus peptides in the context of major histocompatibility complex. This system may be useful for defining the cellular immune response to HCMV and for the treatment of HCMV infection in immunocompromised patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 03:19:21