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Titolo:
Equipotent generation of protective antitumor immunity by various methods of dendritic cell loading with whole cell tumor antigens
Autore:
Lambert, LA; Gibson, GR; Maloney, M; Barth, RJ;
Indirizzi:
Dartmouth Med Sch, Dept Surg, Lebanon, NH USA Dartmouth Med Sch Lebanon NH USA uth Med Sch, Dept Surg, Lebanon, NH USA Norris Cotton Canc Ctr, Lebanon, NH USA Norris Cotton Canc Ctr Lebanon NHUSA s Cotton Canc Ctr, Lebanon, NH USA
Titolo Testata:
JOURNAL OF IMMUNOTHERAPY
fascicolo: 3, volume: 24, anno: 2001,
pagine: 232 - 236
SICI:
1524-9557(200105/06)24:3<232:EGOPAI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE SPECIFIC IMMUNOTHERAPY; APOPTOTIC CELLS; INTERFERON-GAMMA; RANDOMIZED TRIAL; NECROSIS-FACTOR; CUTTING EDGE; COLON-CANCER; STAGE-II; IN-VIVO; IMMUNOGENICITY;
Keywords:
dendritic cells; tumor vaccine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Barth, RJ Dartmouth Coll, Hitchcock Med Ctr, Sect Gen Surg, 1 Med Ctr Dr, Lebanon, NH 03756 USA Dartmouth Coll 1 Med Ctr Dr Lebanon NH USA 03756 n, NH 03756 USA
Citazione:
L.A. Lambert et al., "Equipotent generation of protective antitumor immunity by various methods of dendritic cell loading with whole cell tumor antigens", J IMMUNOTH, 24(3), 2001, pp. 232-236

Abstract

Multiple clinically applicable methods have been used to induce dendritic cells (DCs) to express whole cell tumor antigens, including pulsing DCs with tumor lysate, and mixing DCs with apoptotic or live tumor cells. Herein we demonstrate, using two different tumor systems, that these methods are equipotent inducers of systemic antitumor immunity. Furthermore, tumor lysatepulsed DC vaccines generate more potent antitumor immunity than immunization with irradiated tumor cells plus the classic adjuvant, Corynebacterium parvum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:19:55