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Titolo:
Ginsenoside potentiates NO-mediated neurogenic vasodilatation of monkey cerebral arteries
Autore:
Toda, N; Ayajiki, K; Fujioka, H; Okamura, T;
Indirizzi:
Shiga Univ Med Sci, Dept Pharmacol, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 l, Otsu, Shiga 5202192, Japan
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 1, volume: 76, anno: 2001,
pagine: 109 - 113
SICI:
0378-8741(200106)76:1<109:GPNNVO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITROXIDERGIC NERVE FUNCTION; NITRIC-OXIDE; PANAX-GINSENG; RAT AORTA; ENDOTHELIUM; RELAXATION; STIMULATION; TONE;
Keywords:
nitric; oxide; ginseng extract; vasodilator nerve; monkey cerebral artery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Okamura, T Shiga Univ Med Sci, Dept Pharmacol, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 iga 5202192, Japan
Citazione:
N. Toda et al., "Ginsenoside potentiates NO-mediated neurogenic vasodilatation of monkey cerebral arteries", J ETHNOPHAR, 76(1), 2001, pp. 109-113

Abstract

The aqueous extract of the Panax ginseng (GE) potentiated the relaxation induced by transmural electrical stimulation or nicotine in monkey cerebral arterial strips denuded of the endothelium and partially contracted with prostaglandin F-2 alpha. The response to electrical stimulation was abolishedby tetrodotoxin. whereas that to nicotine was suppressed by hexamethonium. N-G-nitro-L-arginine abolished both of the: neurogenic relaxation. Atropine did not alter the potentiating effect of GE. Relaxations induced by exogenous NO were unaffected by GE. The enhancement by GE, of the neurogenic response, appears to be associated with increment in the synthesis or release of NO from the perivascular nerve. Blockade of muscarinic prejunctional inhibition, superoxide scavenging action and phosphodiesterase inhibition are not involved. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:29:41