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Titolo:
Physical status of the E2 human papilloma virus 16 viral gene in cervical preneoplastic and neoplastic lesions
Autore:
Tonon, SA; Picconi, MA; Bos, PD; Zinovich, JB; Galuppo, J; Alonio, LV; Teyssie, AR;
Indirizzi:
Univ Nacl Misiones, Fac Ciencias Exactas Quim & Nat, Lab Biol Mol Aplicada, RA-3300 Posadas, Misiones, Argentina Univ Nacl Misiones Posadas MisionesArgentina RA-3300 Misiones, Argentina ANLIS Dr Carlos G Malbran, INEI, Serv Virus Oncogen, Buenos Aires, DF, Argentina ANLIS Dr Carlos G Malbran Buenos Aires DF Argentina Aires, DF, Argentina
Titolo Testata:
JOURNAL OF CLINICAL VIROLOGY
fascicolo: 2, volume: 21, anno: 2001,
pagine: 129 - 134
SICI:
1386-6532(200105)21:2<129:PSOTEH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYPE-16 DNA; CANCER; EXPRESSION; AMPLIFICATION; KERATINOCYTES; INTEGRATION; CARCINOMAS; REPRESSION; SIHA; LINK;
Keywords:
human papilloma virus 16; E2; integration; cervical neoplasia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Tonon, SA Univ Nacl Misiones, Fac Ciencias Exactas Quim & Nat, Lab Biol Mol Aplicada, Felix Azara 1552, RA-3300 Posadas, Misiones, Argentina Univ Nacl Misiones Felix Azara 1552 Posadas Misiones Argentina RA-3300
Citazione:
S.A. Tonon et al., "Physical status of the E2 human papilloma virus 16 viral gene in cervical preneoplastic and neoplastic lesions", J CLIN VIRO, 21(2), 2001, pp. 129-134

Abstract

Background: Integration of human papilloma virus (HPV) 16 DNA is considered an important genetic change in cervical lesion progression towards ICC. The viral E2 gene is often disrupted by this process, releasing suppression of viral E6/E7 oncogenes, a key factor for oncogenic progression. Objectives: To evaluate the physical status of HPV 16 E2 gene in cervical preneoplastic and neoplastic lesions and its relation with lesion severity. Study design: A sensitive PCR approach for the detection of an intact E2 HPV 16 genein infected epithelial cells from the cervix with low grade squamous intraepithelial lesion (LGSIL), high grade squamous intraepithelial lesion (HGSIL) and invasive cervical carcinoma (ICC) diagnosis was applied. The correlation between gene disruption and lesion stage was examined. Results: Sixty-two LGSIL, 39 HGSIL and 24 ICC samples were analyzed. Fifty-seven LGSIL [92%], 13 HGSIL [33%] and 4 ICC [17%] showed results compatible with an intactE2 gene, while 5 LGSIL [8%], 26 HGSIL [67%] and 20 ICC [83%] samples gave no signal. Conclusions: HPV 16 E2 gene disruption showed a positive correlation with cervical lesion progression, particularly from LGSIL to HGSIL. Although additional genetic events are very likely to be needed for HGSIL to ICC progression, the E2 gene disruption is a putative early marker to consider in the prognostic analysis of HPV 16 chronically infected women. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:24:29