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Titolo:
Future directions in the management of insomnia
Autore:
Richardson, GS; Roth, T;
Indirizzi:
Henry Ford Hosp, Sleep Disorders & Res Ctr, Detroit, MI 48202 USA Henry Ford Hosp Detroit MI USA 48202 ers & Res Ctr, Detroit, MI 48202 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
, volume: 62, anno: 2001, supplemento:, 10
pagine: 39 - 45
SICI:
0160-6689(2001)62:<39:FDITMO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; SLEEP STATE MISPERCEPTION; MATCHED NORMAL SLEEPERS; PSYCHIATRIC-DISORDERS; LOCUS-COERULEUS; DEPRESSED-PATIENTS; MAJOR DEPRESSION; RESTRAINT-STRESS; INDUCED DECREASE; GROWTH-HORMONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Richardson, GS Henry Ford Hosp, Sleep Disorders & Res Ctr, 2799 W Grand Blvd,CFP-3, Detroit, MI 48202 USA Henry Ford Hosp 2799 W Grand Blvd,CFP-3 Detroit MI USA 48202
Citazione:
G.S. Richardson e T. Roth, "Future directions in the management of insomnia", J CLIN PSY, 62, 2001, pp. 39-45

Abstract

Research on insomnia has provided a number of important new insights, but fundamental deficits in our understanding remain. In considering prioritiesfor future research, 3 areas warrant immediate attention. Fil-st, a causalrelationship between insomnia and the adverse outcomes seen in insomnia patients needs to be established. Second, currently available symptomatic therapies need to be optimized. Recent data suggest that some benzodiazepine receptor agonists produce their hypnotic effect without side effects that were presumed to be inherent to sedation. Understanding the neuropharmacologyunderlying this differential effect would allow substantial improvements in the risk-benefit ratio for these drugs. Finally, the mechanisms of insomnia need to be better understood. Several lines of evidence suggest that physiologic arousal is important to the clinical presentation of primary insomnia. It remains unclear, however, whether this activation is primary or secondary to the insomnia itself. If physiologic hyperarousal causes primary insomnia, it would provide new approaches to the management of this disorder.

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Documento generato il 18/01/20 alle ore 21:58:07