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Titolo:
Oxidative stress and atherosclerosis
Autore:
Yang, TTC; Devaraj, S; Jialal, I;
Indirizzi:
Univ Texas, SW Med Ctr, Div Clin Biochem & Human Metab, Dept Pathol, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 n Metab, Dept Pathol, Dallas, TX 75390 USA
Titolo Testata:
JOURNAL OF CLINICAL LIGAND ASSAY
fascicolo: 1, volume: 24, anno: 2001,
pagine: 13 - 24
SICI:
1081-1672(200121)24:1<13:OSAA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; ALPHA-TOCOPHEROL SUPPLEMENTATION; CORONARY HEART-DISEASE; HUMAN-BLOOD PLASMA; PERFORMANCE LIQUID-CHROMATOGRAPHY; POLYUNSATURATED FATTY-ACIDS; VITAMIN-E SUPPLEMENTATION; HUMAN ENDOTHELIAL-CELLS; IN-VIVO FORMATION; LIPID-PEROXIDATION;
Keywords:
oxidative stress; atherosclerosis; low density lipoprotein; F-2-isoprostanes; antioxidant; alpha-tocopherol;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
151
Recensione:
Indirizzi per estratti:
Indirizzo: Jialal, I Univ Texas, SW Med Ctr, Div Clin Biochem & Human Metab, Dept Pathol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 X 75390 USA
Citazione:
T.T.C. Yang et al., "Oxidative stress and atherosclerosis", J CLIN LIG, 24(1), 2001, pp. 13-24

Abstract

Cardiovascular disease is the leading cause of death in westernized populations. Accumulating evidence suggests that lipid peroxidation is pivotal inatherogenesis. Supplementation with antioxidants, e.g., vitamin E, has been shown in animal models and humans to reduce atherosclerotic lesion progression and cardiovascular events. Methods to evaluate oxidative stress include direct and indirect measures. The most relevant direct measure of oxidative stress is urinary F-2-isoprostanes, which are prostaglandin-like compounds formed in vivo from free radical catalyzed peroxidation of arachidonic acid via a non-cycloxygenase-dependent mechanism. The measurement of F-2-isoprostanes provides a sensitive, specific, and non-invasive method for the assessment of in vivo lipid peroxidation. Other direct measures include autoantibodies to oxidized LDL, and assaying modified LDL in plasma, breath volatile hydrocarbons, and protein carbonyl. Measures of autoantibodies and modified LDL still need further standardization before they can be specific and sensitive direct measures of oxidative stress. Indirect measures of oxidative stress include measurement of total antioxidant capacity (ORAC, TRAP), individual antioxidant status (including glutathione, alpha-tocopherol, carotenoids, and ascorbate) and LDL oxidizability (including conjugated dienes, lipid peroxides, TBARS, apo B-100 fluorescence, and fatty acid content).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 16:01:10