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Titolo:
Recombinant food allergens
Autore:
Lorenz, AR; Scheurer, S; Haustein, D; Vieths, S;
Indirizzi:
Paul Ehrlich Inst, Dept Allergol, D-63225 Langen, Germany Paul Ehrlich Inst Langen Germany D-63225 lergol, D-63225 Langen, Germany
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 756, anno: 2001,
pagine: 255 - 279
SICI:
1387-2273(20010525)756:1-2<255:RFA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BOVINE BETA-LACTOGLOBULIN; BIRCH POLLEN ALLERGEN; HIGH-LEVEL EXPRESSION; CROSS-REACTIVE ALLERGEN; IGE-BINDING EPITOPES; ASPERGILLUS-FUMIGATUS ALLERGENS; MUSCLE PROTEIN TROPOMYOSIN; SITE-DIRECTED MUTAGENESIS; PLASMID DNA IMMUNIZATION; MAJOR CHERRY ALLERGEN;
Keywords:
reviews; food allergy; recombinant food allergen;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
217
Recensione:
Indirizzi per estratti:
Indirizzo: Vieths, S Paul Ehrlich Inst, Dept Allergol, Paul Ehrlich Str 51-59, D-63225 Langen, Germany Paul Ehrlich Inst Paul Ehrlich Str 51-59 Langen Germany D-63225
Citazione:
A.R. Lorenz et al., "Recombinant food allergens", J CHROMAT B, 756(1-2), 2001, pp. 255-279

Abstract

Allergenic (glyco)proteins are the elicitors of food allergies and can cause acute severe hypersensitivity reactions. Recombinant food allergens are available in standardised quantity and constant quality. Therefore, they offer new perspectives to overcome current difficulties in the diagnosis, treatment and investigation of food allergies. This review summarises the expression strategies and characteristics of more than 40 recombinant food allergens that have been produced until today. Their IgE-binding properties arecompared to those of their natural counterparts, in addition their application as diagnostic tools, the generation of hypoallergenic recombinant isoforms and mutants for therapeutic purposes, the determination of epitopes and cross-reactive structures are described. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 06:10:47