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Titolo:
Seasonal variation in food allergy to apple
Autore:
Hansen, KS; Vieths, S; Vestergaard, N; Skov, PS; Bindslev-Jensen, C; Poulsen, LK;
Indirizzi:
Natl Univ Hosp, Dept 7551, Allergy Unit, DK-2100 Copenhagen, Denmark Natl Univ Hosp Copenhagen Denmark DK-2100 t, DK-2100 Copenhagen, Denmark Paul Ehrlich Inst, Dept Allergol, D-6070 Langen, Germany Paul Ehrlich Inst Langen Germany D-6070 Allergol, D-6070 Langen, Germany Odense Univ Hosp, Dept Dermatol, DK-5000 Odense, Denmark Odense Univ HospOdense Denmark DK-5000 ermatol, DK-5000 Odense, Denmark
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 756, anno: 2001,
pagine: 19 - 32
SICI:
1387-2273(20010525)756:1-2<19:SVIFAT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIRCH POLLEN ALLERGEN; SKIN-PRICK TESTS; CROSS-REACTIVITY; MAJOR ALLERGEN; IMMUNOLOGICAL RELATIONSHIP; BET-V-1; IGE; SENSITIVITY; HISTAMINE; MAL-D-1;
Keywords:
food allergy; apples; double-blind placebo-controlled food challenge; seasonal variation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Hansen, KS Natl Univ Hosp, Dept 7551, Allergy Unit, Blegdamsvej 9, DK-2100Copenhagen, Denmark Natl Univ Hosp Blegdamsvej 9 Copenhagen Denmark DK-2100 enmark
Citazione:
K.S. Hansen et al., "Seasonal variation in food allergy to apple", J CHROMAT B, 756(1-2), 2001, pp. 19-32

Abstract

The aim of the study was to investigate the possibility of a seasonal variation in reactivity to apples in 27 birch pollen allergic patients. Before and during the birch pollen season 1998, the patients: were subjected to double-blind, placebo-controlled food challenges (DBPCFCs) with grated fresh Golden Delicious apple followed by an open food challenge with whole fresh apple. The clinical reactions elicited during the challenges were evaluatedboth by the patients and the investigators. Moreover, the skin reactivity and the in vitro reactivity to apple were evaluated by skin prick test (SPT), leukocyte histamine release (HR), measurement of specific IgE, and immunoblotting experiments. The sensitivity of the DBPCFC, when compared with the result of the open challenge, was 0.74 (14/19) before the season and 0.80(16/20) during the season. None of the patients reacted to the blinded challenge without a subsequent reaction to the open challenge. One placebo reaction was registered both before and in season, but not in the same patient. The patient scores of the first positive challenges, and the maximal scores of each combined blinded and open challenge session, were significantly increased during the pollen season (P < 0.05). The scores of the open challenge were significantly higher than the scores of the DBPCFC both before the season and during the in-season challenges (P < 0.05). Specific IgE against Golden Delicious increased during season (P < 0.05), while neither SPT, HR, nor immunoblotting experiments could confirm an increase in reactivity. In conclusion, the results of the oral challenge tests indicated an increase in clinical reactivity to apples during the birch pollen season in birchpollen allergic individuals. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 23:39:19