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Titolo:
Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene
Autore:
Guan, BX; Yue, P; Clayman, GL; Sun, SY;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 d & Neck Med Oncol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030USA Univ Texas Houston TX USA 77030 pt Head & Neck Surg, Houston, TX 77030USA Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 tr, Dept Canc Biol, Houston, TX 77030 USA
Titolo Testata:
JOURNAL OF CELLULAR PHYSIOLOGY
fascicolo: 1, volume: 188, anno: 2001,
pagine: 98 - 105
SICI:
0021-9541(200107)188:1<98:ETTDRD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
WILD-TYPE P53; CYTOTOXIC LIGAND TRAIL; LUNG-CARCINOMA CELLS; NF-KAPPA-B; CANCER-CELLS; HUMAN HEAD; P53-INDEPENDENT REGULATION; SELECTIVE RETINOIDS; DECOY RECEPTORS; KILLER/DR5 GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Sun, SY Univ Texas, MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, 1515 Holcombe Blvd,Box 432, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd,Box 432 Houston TX USA 77030 030 USA
Citazione:
B.X. Guan et al., "Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene", J CELL PHYS, 188(1), 2001, pp. 98-105

Abstract

DR4 (TRAIL-R1), a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that triggers the apoptotic machinery upon binding to its: ligand tumor necrosis factor-related apoptosis-inducing ligand(TRAIL). Although three other TRAIL receptors DR5, DcR1, and DcR2 are induced by DNA damage and are regulated by the wild-type p53 tumor suppressor, it was not known whether these factors also affect DR4 expression. In this study, we found that DR4 expression is also enhanced by DNA damage whether induced by ionizing radiation or by chemotherapeutic agents. The induction was observed predominantly in cells containing wild-type p53 and was similar to the, regulation patterns of DR5 and Fas, two other members of the family which are known to be regulated by p53. Transfection of HPV 16 E6 gene into cells with wild-type p57, which decreased the level of p53 protein, resulted in suppression of DR4 induction by DNA-damaging agents. Conversely, introduction of exogenous wild-type p53 through adenovirus infection has ledto upregulation of endogenous DR4 in cells with mutant p53. Moreover, the transcription inhibitor actinomycin D abolished DNA-damaging agent-induced DR4 expression. Thus, DR4 appears to be a DNA damage-inducible, p53-regulated gene. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:06:54