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Titolo:
Exercise training activates large-conductance calcium-activated K+ channels and enhances nitric oxide production in rat mesenteric artery and thoracic aorta
Autore:
Chen, SJ; Wu, CC; Yen, MS;
Indirizzi:
Natl Def Med Ctr, Dept Pharmacol, Tokyo 114, Japan Natl Def Med Ctr Tokyo Japan 114 d Ctr, Dept Pharmacol, Tokyo 114, Japan
Titolo Testata:
JOURNAL OF BIOMEDICAL SCIENCE
fascicolo: 3, volume: 8, anno: 2001,
pagine: 248 - 255
SICI:
1021-7770(200105/06)8:3<248:ETALCK>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-MEDIATED DILATION; DEPENDENT PROTEIN-KINASE; SPONTANEOUSLY HYPERTENSIVE RATS; CORONARY RESISTANCE ARTERIES; SMOOTH-MUSCLE CELLS; RELAXING FACTOR; BLOOD-FLOW; RESPONSES; HYPERPOLARIZATION; ACETYLCHOLINE;
Keywords:
exercise; nitric oxide; K+ channels; vascular reactivity; mesenteric arteries; thoracic aortas; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, SJ Natl Def Med Ctr, Dept Pharmacol, POB 90048-504, Tokyo 114, JapanNatl Def Med Ctr POB 90048-504 Tokyo Japan 114 Tokyo 114, Japan
Citazione:
S.J. Chen et al., "Exercise training activates large-conductance calcium-activated K+ channels and enhances nitric oxide production in rat mesenteric artery and thoracic aorta", J BIOMED SC, 8(3), 2001, pp. 248-255

Abstract

Exercise training has reversible beneficial effects on cardiovascular diseases, e.g. hypertension, which may result from a decrease in systemic vascular resistance. The purpose of this study was to investigate possible mechanisms associated with the changes in vascular reactivity in large and smallarteries with vasoconstrictors and vasodilators in rats after exercise. Wistar-Kyoto rats were trained far 8 weeks (Ex group) on a treadmill and compared with sedentary counterparts (Sed group). After the measurement of blood pressure and heart rate at 8 weeks, rat mesenteric arteries and thoracic aortas were excised and prepared as rings for this study. In addition, special care was taken not to damage the endothelium of the preparations. Our results showed that exercise training for 8 weeks (1) not only prevented an increase in blood pressure but also caused a fall in heart rate, (2) attenuated the contractions induced by both prostaglandin F-2 alpha (PGF(2 alpha)) and high K+ in the mesenteric artery, but reduced the PGF(2 alpha)-induced contraction in the aorta only, (3)enhanced the relaxation elicited by acetylcholine (ACh) in both mesenteric arteries and aortas, and (4) increased nitrate [an indicator of nitric oxide (NO) formation] in plasma. The enhancement of ACh-induced relaxation in the mesenteric arteries in the Ex group was suppressed by pretreatment with N-omega-nitro-L-arginine methyl ester (L-NAME), tetraethylammonium (TEA; a nonselective inhibitor of K+ channels) or charybdotoxin [CTX; a selective inhibitor of large-conductance calcium-activated K+ (BKCa) channels], whereas in the aorta that response was attenuated by TEA or CTX and almost completely abolished by L-NAME. However, witha combination of L-NAME plus CTX in the mesenteric artery, ACh-induced relaxation was completely abolished in the Sed group, but not in the Ex group. These results suggest that in addition to NO, activation of BKCa channels in the vascular beds, at least in part, also contributes to vasodilatation in animals with exercise training.

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Documento generato il 11/07/20 alle ore 02:50:17