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Titolo:
Theoretical analysis of shape transformation of V-79 cells after treatmentwith cytochalasin B
Autore:
Iglic, A; Veranic, P; Batista, U; Kralj-Iglic, V;
Indirizzi:
Univ Ljubljana, Fac Elect Engn, Appl Phys Lab, SI-1000 Ljubljana, SloveniaUniv Ljubljana Ljubljana Slovenia SI-1000 b, SI-1000 Ljubljana, Slovenia Univ Ljubljana, Fac Med, Inst Cell Biol, SI-1000 Ljubljana, Slovenia Univ Ljubljana Ljubljana Slovenia SI-1000 l, SI-1000 Ljubljana, Slovenia Univ Ljubljana, Fac Med, SI-1000 Ljubljana, Slovenia Univ Ljubljana Ljubljana Slovenia SI-1000 d, SI-1000 Ljubljana, Slovenia
Titolo Testata:
JOURNAL OF BIOMECHANICS
fascicolo: 6, volume: 34, anno: 2001,
pagine: 765 - 772
SICI:
0021-9290(200106)34:6<765:TAOSTO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID BILAYER; DEFORMATION; MEMBRANE; MICROTUBULES; FIBROBLASTS; MECHANICS; VESICLES; ENERGY;
Keywords:
cell shape; cytoskeleton; elastic energy; cortical shell; vesiculation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Iglic, A Univ Ljubljana, Fac Elect Engn, Appl Phys Lab, Trazaska 25, SI-1000 Ljubljana, Slovenia Univ Ljubljana Trazaska 25 Ljubljana Slovenia SI-1000 , Slovenia
Citazione:
A. Iglic et al., "Theoretical analysis of shape transformation of V-79 cells after treatmentwith cytochalasin B", J BIOMECHAN, 34(6), 2001, pp. 765-772

Abstract

We observed that after treatment of V-79 fibroblasts with cytochalasin B the area of cell contact with the substrate is essentially reduced, the microtubules are organized into rodlike structures and the actin filaments are disintegrated. Remnants of the actin cortex become concentrated in the formof discrete patches under the plasma membrane. The described changes in the organization of the cytoskeleton and of the cortical shell are accompanied by the formation of a cell shape resembling the Greek letter phi. We calculated that the phi shape corresponds to the minimum of the stretching energy of the cortical shell at relevant geometrical constraints. III line withthis result, if cytochalasin B treatment was followed by colchicine application which disrupted the microtubular rod, the characteristic phi shape completely disappeared. This study suggests that the effect of the microtubular rod on the cell shape can be theoretically well described by taking intoaccount some basic conditions For the mechanical equlibrium of the cell cortical shell and the appropriate geometrical constraints. (C) 2001 ElsevierScience Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:13:17