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Titolo:
Amplification of mutator cells in a population as a result of horizontal transfer
Autore:
Funchain, P; Yeung, A; Stewart, J; Clendenin, WM; Miller, JH;
Indirizzi:
Univ Calif Los Angeles, Dept Microbiol & Mol Genet, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
JOURNAL OF BACTERIOLOGY
fascicolo: 12, volume: 183, anno: 2001,
pagine: 3737 - 3741
SICI:
0021-9193(200106)183:12<3737:AOMCIA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESCHERICHIA-COLI; MISMATCH-REPAIR; COLORECTAL-CANCER; MICROSATELLITE INSTABILITY; SALMONELLA-TYPHIMURIUM; GENETIC-RECOMBINATION; MUTATIONS; HOMOLOG; BACTERIA; GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, JH Univ Calif Los Angeles, Dept Microbiol & Mol Genet, 405 HilgardAve, Los Angeles, CA 90095 USA Univ Calif Los Angeles 405 Hilgard Ave Los Angeles CA USA 90095
Citazione:
P. Funchain et al., "Amplification of mutator cells in a population as a result of horizontal transfer", J BACT, 183(12), 2001, pp. 3737-3741

Abstract

Mutator cells that lack the mismatch repair system (MMR-) occur at rates of 10(-5) or less in laboratory populations started from wild-type cells. Weshow that after selection for recombinants in an interspecies mating between Salmonella enterica serovar Typhimurium and Escherichia coli, the percentage of MMR- cells rises to several percent of the recombinant population, and after a second successive mating and selection, greater than 95% of therecombinants are MMR-. Coupling a single cross and selection,vith either mutagenesis or selection for spontaneous mutants also results in a dramatic increase in MMR- cells. We discuss how horizontal transfer can result in mutator strains during adaptive evolution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:49:32