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Titolo:
Antifungal mechanism of polygodial
Autore:
Kubo, I; Fujita, K; Lee, SH;
Indirizzi:
Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 agement, Berkeley, CA 94720 USA
Titolo Testata:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
fascicolo: 3, volume: 49, anno: 2001,
pagine: 1607 - 1611
SICI:
0021-8561(200103)49:3<1607:AMOP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SESQUITERPENE DIALDEHYDES; SACCHAROMYCES-CEREVISIAE; ANTIMICROBIAL AGENTS; ACIDIFICATION; CHOLESTEROL; MEMBRANES; GLUCOSE; ATPASE; CELLS; ACID;
Keywords:
antifungal activity; Saccharomyces cerevisiae; polygodial; surfactant property; acidification; H+-ATPase; lipid-protein interface;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kubo, I Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 Berkeley, CA 94720 USA
Citazione:
I. Kubo et al., "Antifungal mechanism of polygodial", J AGR FOOD, 49(3), 2001, pp. 1607-1611

Abstract

The primary antifungal action of polygodial comes in part from its abilityto function Bs a nonionic surfactant, disrupting the lipid-protein interface of integral proteins and denaturing their conformation. As a result, theantifungal mechanism of this sesquiterpene dialdehyde is associated with the membrane functions or derangement of the:membrane. For example, the glucose-induced medium acidification process of Saccharomyces cerevisiae was inhibited by polygodial presumably caused by inhibition of the plasma membrane H+-ATPase. However, the potent antifungal activity of polygodial results from its multiple functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:24:36