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Titolo:
Mechanism of atropine-resistant contraction induced by Dai-kenchu-to in guinea pig ileum
Autore:
Satoh, K; Hashimoto, K; Hayakawa, T; Ishige, A; Kaneko, M; Ogihara, S; Kurosawa, S; Yakabi, K; Nakamura, T;
Indirizzi:
Tsumura & Co, Kampo & Pharmacognosy Lab, R&D Div, Ami, Ibaraki 3001192, Japan Tsumura & Co Ami Ibaraki Japan 3001192 D Div, Ami, Ibaraki 3001192, Japan Teikyo Univ, Dept Internal Med 3, Sch Med, Ichihara Hosp, Chiba 2990111, Japan Teikyo Univ Chiba Japan 2990111 Med, Ichihara Hosp, Chiba 2990111, Japan
Titolo Testata:
JAPANESE JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 86, anno: 2001,
pagine: 32 - 37
SICI:
0021-5198(200105)86:1<32:MOACIB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANCE-P ANTAGONISTS; CAPSAICIN; RESPONSES; MOTILITY; PIPERINE; NEURONS; OLVANIL;
Keywords:
Dai-kenchu-to; Zanthoxylum fruit; hydroxy beta-sanshool; intestinal motility; tachykinin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Satoh, K Tsumura & Co, Kampo & Pharmacognosy Lab, R&D Div, 3586 Yoshiwara,Ami, Ibaraki 3001192, Japan Tsumura & Co 3586 Yoshiwara Ami Ibaraki Japan 3001192 1192, Japan
Citazione:
K. Satoh et al., "Mechanism of atropine-resistant contraction induced by Dai-kenchu-to in guinea pig ileum", JPN J PHARM, 86(1), 2001, pp. 32-37

Abstract

To clarify the contractile mechanism of Dai-kenchu-to, the effects of hydroxy beta -sanshool tan ingredient of Zanthoxylum fruit), Zanthoxylum fruit (a constituent herb of Dai-kenchu-to) and Dai-kenchu-to were studied in mucosa-free longitudinal muscle of guinea pig ileum. Hydroxy beta -sanshool at10(-7) - 10(-5) g/ml induced dose-related contractions accompanied by autonomous contraction and produced an initial contraction at a concentration of 10(-4) g/ml or more. The contraction induced by hydroxy beta -sanshool (10(-5) g/ml) was significantly inhibited by tetrodotoxin or the capsaicin-receptor antagonist capsazepine. Although atropine or the substance P antagonist spantide tended to inhibit the contraction, a combination of atropine and spantide almost abolished the contraction by hydroxy beta -sanshool, TheP-2-purinoceptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid did not affect hydroxy beta -sanshool-induced contraction in the presence or absence of spantide. The tonic contractions by Zanthoxylum fruit(2 x 10(-4) g/ml) and Dai-kenchu-to (10(-3) g/ml) were significantly inhibited or tended to be inhibited by atropine, spantide, tetrodotoxin or capsazepine and were remarkably suppressed by the combination of atropine and spantide. These results suggested that acetylcholine release from intrinsic cholinergic nerves and tachykinins from sensory neurons are involved in the contractions induced by hydroxy beta -sanshool and that tachykinins may be involved in the atropine-resistant contraction by Dai-kenchu-to.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:13:38