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Titolo:
Urokinase receptor and vascular endothelial growth factor are synergistically associated with the liver metastasis of colorectal cancer
Autore:
Konno, H; Abe, J; Kaneko, T; Baba, M; Shoji, A; Sunayama, K; Kamiya, K; Tanaka, T; Suzuki, S; Nakamura, S; Urano, T;
Indirizzi:
Hamamatsu Univ, Sch Med, Dept Surg 2, Shizuoka 4313192, Japan Hamamatsu Univ Shizuoka Japan 4313192 pt Surg 2, Shizuoka 4313192, Japan Hamamatsu Univ, Sch Med, Dept Physiol 2, Shizuoka 4313192, Japan HamamatsuUniv Shizuoka Japan 4313192 Physiol 2, Shizuoka 4313192, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 5, volume: 92, anno: 2001,
pagine: 516 - 523
SICI:
0910-5050(200105)92:5<516:URAVEG>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR-1; PERMEABILITY FACTOR; TUMOR ANGIOGENESIS; GASTRIC-CARCINOMA; PROGNOSTIC FACTOR; CELL-MIGRATION; BREAST-CANCER; COLON-CANCER; EXPRESSION; INVASION;
Keywords:
urokinase-type plasminogen activator (uPA); uPA receptor (uPAR); plasminogen activator inhibitor type 1 (PAI-1); vascular endothelial growth factor (VEGF); microvessel density (MVD);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Konno, H Hamamatsu Univ, Sch Med, Dept Surg 2, 3600 Handa Cho, Shizuoka 4313192, Japan Hamamatsu Univ 3600 Handa Cho Shizuoka Japan 4313192 3192, Japan
Citazione:
H. Konno et al., "Urokinase receptor and vascular endothelial growth factor are synergistically associated with the liver metastasis of colorectal cancer", JPN J CANC, 92(5), 2001, pp. 516-523

Abstract

Considering recent findings that the urokinase plasminogen activation (PA)system is involved in invasion and vascular endothelial growth factor (VEGF) is involved in angiogenesis of colorectal cancer, we evaluated these factors in the liver metastasis of primary colorectal cancer. Canter tissues from 71 colorectal cancer patients were assayed quantitatively for antigen levels of urokinase type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor-1 and -2 (PAI-1, PAI-2), and were also assayed immunohistochemically for expression of VEGF protein. Among the PA system factors, both the levels of uPAR and PAI-1 were significantly higher in larger tumors than in smaller ones, and were also significantly higher in tumors that invaded subserosa, serosa or adjacent organs than in mucosal,submucosal tumors or in tumors that invaded the muscle layer. The uPAR levels were significantly higher in tumors with liver metastasis than in thosewithout. VEGF overexpression was significantly more frequent in tumors with 12 mph node involvement or liver metastasis than in those without. Among the PA system factors, the uPAR levels were significantly higher in tumors with VEGF overexpression and a multivariate analysis revealed that high uPAlevel and VEGF overexpression were independent risk factors for liver metastasis. The combination of high uPAR level and overexpression of VEGF was associated with the worst prognosis in patients with colorectal cancer. These results suggest that uPAR and VEGF might contribute synergistically to the liver metastasis of colorectal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:48:32