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Titolo:
Low expression myeloperoxidase genotype negatively associated with Helicobacter pylori infection
Autore:
Hamajima, N; Matsuo, K; Suzuki, T; Nakamura, T; Matsuura, A; Tajima, K; Tominaga, S;
Indirizzi:
Aichi Canc Ctr, Div Epidemiol & Prevent, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 u, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr, Dept Gastroenterol, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 u, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr, Res Inst, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 u, Nagoya, Aichi 4648681, Japan Nagoya Univ, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 5, volume: 92, anno: 2001,
pagine: 488 - 493
SICI:
0910-5050(200105)92:5<488:LEMGNA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; LUNG-CANCER RISK; GASTRIC-CANCER; CELLS; POLYMORPHISM; AMOXICILLIN; ERADICATION; NEUTROPHILS; OMEPRAZOLE; ANTIBODY;
Keywords:
Helicobacter pylori infection; myeloperoxidase; lifestyle factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Hamajima, N Aichi Canc Ctr, Div Epidemiol & Prevent, Chikusa Ku, 1-1 Kanokoden, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr 1-1 Kanokoden Nagoya Aichi Japan 4648681 Japan
Citazione:
N. Hamajima et al., "Low expression myeloperoxidase genotype negatively associated with Helicobacter pylori infection", JPN J CANC, 92(5), 2001, pp. 488-493

Abstract

Our previous study revealed that a polymorphism of the interleukin (IL) 1Bgene, encoding the pro-inflammatory cytokine IL-IP, influenced the prevalence of persistent Helicobacter pylori (HP) infection, In this paper, a polymorphism of another inflammation-related enzyme, myeloperoxidase (MPO), wasexamined with respect to association with the HP infection, The pal? morphism is due to a G-to-A transition at -463 in the promoter region of MPO. The G allele is the wild type with normal expression, while the A allele is alow expression allele, The subjects were 241 non-cancer outpatients (118 males and 123 females) aged 39 to 69 who participated in an HP eradication program at Aichi Cancer Center Hospital, High-molecular weight Campylobacter-Associated-Protein (HM-CAP) ELISA (Enteric Products Ins., Westbury, NY) was used for the identification of HP-infected participants, The frequency was 79.7% (192/241) for the GC genotype, 19.5 % (47/241) for the GA genotype,and 0.8% (2/241) for the AA genotype, The sex-age-adjusted odds ratio (OR)relative to GG was 0.69 (95% confidence interval (CI), 0.35-1.35) for individuals with the A allele, but among male participants the OR was 0.31 (0.11-0.84). Subgroup analysis revealed significantly reduced ORs with the GA/AA genotypes for current smokers (0,19, 0.04-0.96), and for those who were occasional/no milk drinkers (0,25, 0,09-0,72). These findings are consistentwith the results for IL-1B in our earlier study, suggesting that inflammatory responses in the gastric mucosa may influence persistent HP infection, and that smoking and milk intake may be effect-modifiers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 11:52:11