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Titolo:
A genetic analysis of weight and overweight in 4-year-old twin pairs
Autore:
Koeppen-Schomerus, G; Wardle, J; Plomin, R;
Indirizzi:
Univ London Kings Coll, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England Univ Coll London, Dept Epidemiol & Publ Hlth, London, England Univ Coll London London England Epidemiol & Publ Hlth, London, England
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 6, volume: 25, anno: 2001,
pagine: 838 - 844
SICI:
0307-0565(200106)25:6<838:AGAOWA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-REGRESSION ANALYSIS; BODY-MASS INDEX; OBESITY; CHILDREN; ETIOLOGY; SAMPLE;
Keywords:
weight; overweight; twin studies; genes; environment; childhood; quantitative trait locus; QTL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Koeppen-Schomerus, G Univ London Kings Coll, Inst Psychiat, Social Genet &Dev Psychiat Res Ctr, 113 Denmark Hill, London WC2R 2LS, England Univ London Kings Coll 113 Denmark Hill London England WC2R 2LS
Citazione:
G. Koeppen-Schomerus et al., "A genetic analysis of weight and overweight in 4-year-old twin pairs", INT J OBES, 25(6), 2001, pp. 838-844

Abstract

OBJECTIVE: Although many twin and adoption studies document genetic influence on individual differences in weight, much less is known about genetic influences on overweight, about the genetic links between weight and overweight, or about the origins of weight and overweight in childhood, an age that might provide a good target for prevention of obesity We tested the hypothesis that, in early childhood, overweight is as heritable as weight and that weight and overweight are linked geneticallyDESIGN: Model-fitting analyses were used to compare monozygotic (MZ) and dizygotic (DZ) twins (same-sex and opposite-sex) for weight and overweight. SUBJECTS: The sample included 3636 4-y-old twins born in the UK in 1994. MEASUREMENTS: Heights and weights reported by parents were used to assess weight corrected for height, which yields results similar to body mass index (BMI) but corrects more completely for genetic effects on height. RESULTS: At 4y of age, genetic factors contributed substantially both to individual differences in weight throughout the distribution and to the meanweight difference between overweight children and the rest of the population. Unlike results later in life, weight and overweight in 4-y-olds also suggest substantial shared family environmental influence. Results are similar for boys and girls. CONCLUSIONS: Overweight is the quantitative extreme of genetic and environmental factors responsible for normal variation in weight in childhood. Genes associated with overweight are likely to be associated with variation inweight throughout the distribution, as assumed by quantitative trait locus(QTL) theory. These findings linking weight and overweight in childhood have far-reaching implications for molecular genetic attempts to identify specific genes responsible for genetic influence, for investigating pathways between genes and behaviour, and for intervention and prevention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 21:08:24