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Titolo:
The effect of physiological levels of glucagon-like peptide-1 on appetite,gastric emptying, energy and substrate metabolism in obesity
Autore:
Flint, A; Raben, A; Ersboll, AK; Holst, JJ; Astrup, A;
Indirizzi:
Royal Vet & Agr Univ, Res Dept Human Nutr, Ctr Food Res, DK-1958 Frederiksberg C, Denmark Royal Vet & Agr Univ Frederiksberg Denmark C 58 Frederiksberg C, Denmark Royal Vet & Agr Univ, Dept Anim Sci & Anim Hlth, DK-1870 Frederiksberg, Denmark Royal Vet & Agr Univ Frederiksberg Denmark DK-1870 rederiksberg, Denmark Univ Copenhagen, Panum Inst, Dept Med Physiol, DK-2200 Copenhagen N, Denmark Univ Copenhagen Copenhagen Denmark N siol, DK-2200 Copenhagen N, Denmark
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 6, volume: 25, anno: 2001,
pagine: 781 - 792
SICI:
0307-0565(200106)25:6<781:TEOPLO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETICS; FOOD-INTAKE; SECRETION; SATIETY; PLASMA; EXPENDITURE; GLUCOSE; HUMANS; GLP-1; MEAL;
Keywords:
resting metabolic rate; thermogenesis; oxidation; energy intake; satiety; hunger; glucagon; insulin; GIP; GLP-1; GLP-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Flint, A Royal Vet & Agr Univ, Res Dept Human Nutr, Ctr Food Res, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark Royal Vet & Agr Univ Rolighedsvej30 Frederiksberg Denmark C ark
Citazione:
A. Flint et al., "The effect of physiological levels of glucagon-like peptide-1 on appetite,gastric emptying, energy and substrate metabolism in obesity", INT J OBES, 25(6), 2001, pp. 781-792

Abstract

OBJECTIVE: Peripheral infusions of glucagon-like peptide-1 (GLP-1) in humans have been shown to inhibit gastrointestinal motility and decrease hungerand energy intake. However, these investigations used supraphysiological doses. The objective of this study was to investigate the effects of a GLP-1infusion in a physiological dose on appetite sensations, energy intake, gastric emptying, energy and substrate metabolism. METHODS: Eighteen obese men participated in the placebo-controlled, randomized, single-blinded, cross-over study with infusion of GLP-1 or saline. Resting metabolic rate (RMR) and substrate oxidations were measured by ventilated hood before and after an energy-fixed breakfast. Gastric emptying was measured using paracetamol as a marker. Visual analogue scales were used toassess appetite sensations, thirst and comfort throughout the experiment and palatability of the test meals. Blood was sampled for analysis of hormones (GLP-1, GLP-2, glucose-dependent insulinotropic polypeptide (GIP), insulin, glucagon), and substrates (glucose, lactate, non-esterified fatty acids(NEFA), triacylglycerol (TAG)). Ad libitum energy intake at lunch was registered. RESULTS: Following the breakfast, GLP-1 infusion suppressed ratings of hunger and prospective food consumption (P < 0.05), whereas all other subjective ratings and ad libitum energy intake were unaffected. RMR, carbohydrate oxidation and gastric emptying rate were lower during the GLP-1 infusion compared with the saline infusion (P < 0.001, P < 0.05, P < 0.0001, respectively). All plasma hormone and substrate profiles, except NEFA, were significantly reduced by GLP-1 (P < 0.0001). CONCLUSION: It is concluded that GLP-1 in physiological concentrations powerfully reduces the rate of entry of nutrients into the circulation by a reduction of gastric emptying rate in obese subjects. The effect of GLP-1 on appetite and food intake may be beneficial in weight reduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:29:29