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Titolo:
Synergistic effect of polymorphisms of uncoupling protein 1 and ss 3-adrenergic receptor genes on autonomic nervous system activity
Autore:
Shihara, N; Yasuda, K; Moritani, T; Ue, H; Uno, M; Adachi, T; Nunoi, K; Seino, Y; Yamada, Y; Tsuda, K;
Indirizzi:
Kyoto Univ, Fac Integrated Human Studies, Lab Metab, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Lab Metab, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ, Grad Sch Human & Environm Studies, Lab Metab, Kyoto, Japan Kyoto Univ Kyoto Japan uman & Environm Studies, Lab Metab, Kyoto, Japan Kyoto Univ, Grad Sch Med, Dept Metab & Clin Nutr, Kyoto, Japan Kyoto UnivKyoto Japan ad Sch Med, Dept Metab & Clin Nutr, Kyoto, Japan Kyoto Univ, Grad Sch Human & Environm Studies, Appl Physiol Lab, Kyoto, Japan Kyoto Univ Kyoto Japan Environm Studies, Appl Physiol Lab, Kyoto, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 6, volume: 25, anno: 2001,
pagine: 761 - 766
SICI:
0307-0565(200106)25:6<761:SEOPOU>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; HEART-RATE-VARIABILITY; BETA(3)-ADRENERGIC RECEPTOR; SPECTRAL-ANALYSIS; WEIGHT-GAIN; OBESITY; MUTATION; JAPANESE; THERMOGENESIS; ASSOCIATION;
Keywords:
ss 3-adrenergic receptor; uncoupling protein 1; polymorphism; autonomic nervous system activity; power spectral analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuda, K Kyoto Univ, Fac Integrated Human Studies, Lab Metab, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 , Sakyo Ku, Kyoto 6068501, Japan
Citazione:
N. Shihara et al., "Synergistic effect of polymorphisms of uncoupling protein 1 and ss 3-adrenergic receptor genes on autonomic nervous system activity", INT J OBES, 25(6), 2001, pp. 761-766

Abstract

OBJECTIVE: To investigate the association of the promoter region -3826 A to C polymorphism of the uncoupling protein 1 (UCP1) gene with autonomic nervous system (ANS) activity and the interaction of the polymorphism with theTrp64Arg polymorphism of the beta3 adrenergic receptor (beta 3AR). SUBJECTS: Three-hundred and forty-nine young (mean age 20.4 +/- 2.1 y old), healthy Japanese males. MEASUREMENTS: DNA was extracted from whole blood and genotyped by polymerase chain reaction restriction fragment length polymorphism. Plasma glucose,plasma insulin and body mass index (BMI) were measured. Frequency of family history of diabetes or obesity was determined by interview. Subjects randomly chosen from each genotype were examined for ANS activity during supinerest and standing by electrocardiogram power spectral analysis of heart rate variability. RESULTS: UCP1 or beta 3AR polymorphism was not associated with BMI, plasmaglucose, plasma insulin and frequency of family history of diabetes or obesity. The inhibitory effect of UCP1 polymorphism on ANS activity was observed only with occurrence of the variant of beta 3AR. The very low frequency component associated with thermoregulation in the sympathetic nervous system of homozygotes of UCP1 (CC) at supine rest was significantly lower than normal (AA, 203.2 +/- 50.3 vs 462.2 +/- 83.6 ms(2); mean +/- s.e., P = 0.021). A higher response to postural change to standing was also observed in both sympathetic and parasympathetic nervous activities of AA than of GG. CONCLUSION: While UCP1 polymorphism alone does not affect ANS activity, ithas a synergistic effect with beta 3AR polymorphism in decreasing sympathetic nervous system activity.

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Documento generato il 21/01/20 alle ore 06:58:51