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Titolo:
Experimental Helicobacter pylori infection of Rhesus macaques (Macaca mulatta)
Autore:
Matz-Rensing, K; Kunz, E; Kraft, C; Lorenzen, D; Suerbaum, S; Kaup, FJ;
Indirizzi:
German Primate Ctr, Dept Vet Med & Primate Husb, D-37077 Gottingen, Germany German Primate Ctr Gottingen Germany D-37077 D-37077 Gottingen, Germany German Primate Ctr, Dept Virol & Immunol, D-37077 Gottingen, Germany German Primate Ctr Gottingen Germany D-37077 D-37077 Gottingen, Germany Univ Wurzburg, Inst Hyg & Microbiol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 robiol, D-97080 Wurzburg, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
fascicolo: 1, volume: 291, anno: 2001,
pagine: 33 - 43
SICI:
1438-4221(200104)291:1<33:EHPIOR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONHUMAN-PRIMATES; ANIMAL-MODELS; GASTRITIS; MONKEYS; IDENTIFICATION; FASCICULARIS; BACTERIA; DISEASE;
Keywords:
animal model; experimental infection; H. pylori; rhesus monkey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Matz-Rensing, K German Primate Ctr, Dept Vet Med & Primate Husb, Kellnerweg 4, D-37077 Gottingen, Germany German Primate Ctr Kellnerweg 4 Gottingen Germany D-37077
Citazione:
K. Matz-Rensing et al., "Experimental Helicobacter pylori infection of Rhesus macaques (Macaca mulatta)", INT J MED M, 291(1), 2001, pp. 33-43

Abstract

The aim of the present study was to establish an animal model for Helicobacter pylori (H. pylori) infection at the German Primate Centre in rhesus monkeys (Macaca mulatta). During the experiments the susceptibility of three animals to different H. pylori strains of human origin was tested. In a follow-up study gastric biopsies from three different sites were investigated in regular intervals using microbiological, histological, electron microscopical and molecular biological methods to evaluate the presence of bacterial colonization and the occurrence of gastritis. It was possible to establish a persistent experimental infection. The rather long follow-up period of 18 months offered the possibility to demonstrate a permanent H. pylori infection in the gastric mucosa of the test animals. The three animals have nowbeen successfully colonized with H. pylori for 18 months and presented a chronic active gastritis confirmed by microbiological and histological methods. By molecular typing, the identity of the isolates recovered from the animals was shown. It was possible to demonstrate that one infection strain outcompeted the second one. Taken together, prerequisites exist for making use of an attractive and useful animal model in rhesus monkeys especially for long term observations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:16:18