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Titolo:
A feasibility study of antidepressant drug therapy in depressed elderly patients with chronic obstructive pulmonary disease
Autore:
Yohannes, AM; Connolly, MJ; Baldwin, RC;
Indirizzi:
Manchester Royal Infirm, Manchester Sch Physiotherapy, Manchester M13 9WL,Lancs, England Manchester Royal Infirm Manchester Lancs England M13 9WL L,Lancs, England Manchester Royal Infirm, Dept Old Age Psychiat, Manchester M13 9WL, Lancs,England Manchester Royal Infirm Manchester Lancs England M13 9WL L, Lancs,England Univ Manchester, Manchester Royal Infirm, Dept Geriatr Med, Manchester M139WL, Lancs, England Univ Manchester Manchester Lancs England M13 9WL r M139WL, Lancs, England
Titolo Testata:
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
fascicolo: 5, volume: 16, anno: 2001,
pagine: 451 - 454
SICI:
0885-6230(200105)16:5<451:AFSOAD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDICAL INPATIENTS; TRIAL;
Keywords:
old age; depression; antidepressant treatment; fluoxetine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Yohannes, AM Manchester Royal Infirm, Manchester Sch Physiotherapy, OxfordRd, Manchester M13 9WL, Lancs, England Manchester Royal Infirm Oxford Rd Manchester Lancs England M13 9WL
Citazione:
A.M. Yohannes et al., "A feasibility study of antidepressant drug therapy in depressed elderly patients with chronic obstructive pulmonary disease", INT J GER P, 16(5), 2001, pp. 451-454

Abstract

Objectives To examine the acceptability of fluoxetine in elderly depressedpatients: with chronic obstructive pulmonary disease (COPD). Setting A university teaching hospital. Method Single-blinded (open) study. One hundred and thirty-seven outpatients (69 male) with symptomatic irreversible, moderate to severe COPD were recruited. Major depression was diagnosed using the Geriatric Mental State Schedule. Quality of life was assessed by the Breathing Problem?; Questionnaire, physical disability by the Manchester Respiratory Activities of Daily Living Questionnaire and severity of depression using the Montgomery Asberg Depression Rating Scale. Exclusion criteria were: use of oral steroids within 6 weeks, acute or chronic confusion, known cancer and known psychosis. Results Fifty-seven patients (42%) (25 males) with a mean age of 72 years (range 60-89 years) were depressed. Fourteen (six male) agreed to undergo therapy with fluoxetine 20 mg/day for 6 months, while 36 (72%) refused antidepressant drug therapy. Only seven subjects completed the trial; of these, four (57%) responded to fluoxetine therapy. Five subjects withdrew because of side-effects. Twenty-two of those who refused treatment (61%) agreed to be interviewed, and of these 19 (86%) were still depressed. Conclusion Patient acceptance of fluoxetine was poor. The reasons for refusing treatment varied but were largely due to misapprehension by the patient. Untreated depression became chronic. Offering antidepressants to COPD patients with depression is not an effective strategy. Why this might be so is discussed. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:42:11