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Titolo:
Effects of prenatal ionizing irradiation on the development of the ganglion cell layer of the mouse retina
Autore:
Schmidt, SL; Vitral, RWF; Linden, R;
Indirizzi:
Univ Estado Rio De Janeiro, Lab Neurofisol & Avaliacao Neurocomportamental, BR-20551030 Rio De Janeiro, RJ, Brazil Univ Estado Rio De Janeiro Rio DeJaneiro RJ Brazil BR-20551030 BC Brazil Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, RJ, Brazil Univ Fed Rio de Janeiro Rio De Janeiro RJ Brazil BR-21941 iro, RJ, Brazil
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
fascicolo: 4, volume: 19, anno: 2001,
pagine: 469 - 473
SICI:
0736-5748(200107)19:4<469:EOPIIO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-IRRADIATION; CORPUS-CALLOSUM; AMACRINE CELLS; TIME COURSE; DEATH; MICE; DIFFERENTIATION; SIZE;
Keywords:
ganglion cells; amacrine cells; gamma radiation; retina;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Schmidt, SL Univ Estado Rio De Janeiro, Lab Neurofisol & Avaliacao Neurocomportamental, Ave 28 Setembro 87 Fundos 5 Andar,Vila Isabel, BR-20551030 Rio De Janeiro, RJ, Brazil Univ Estado Rio De Janeiro Ave 28 Setembro 87 Fundos 5 Andar,Vila Isabel Rio De Janeiro RJ Brazil BR-20551030 BC
Citazione:
S.L. Schmidt et al., "Effects of prenatal ionizing irradiation on the development of the ganglion cell layer of the mouse retina", INT J DEV N, 19(4), 2001, pp. 469-473

Abstract

Prenatal exposure to ionizing irradiation has been shown to be an effective method to eliminate selectively certain neuronal population. This investigation studied the effects on the ganglion cell layer of the retinae of adult mice exposed to a gamma source (total dose = 3 Gy) at 16 days gestation. There was 3 significant reduction in the total number of neurons (displaced amacrine + ganglion cells) in the ganglion cell layer (33%) that was mainly caused by a pronounced loss (59%) of displaced amacrine cells. The diameters of the surviving retinal ganglion cells were consistently larger than those of the controls. Prenatal irradiation is the first experimental approach that partially eliminates displaced amacrine cells. It is suggested that the morphogenesis of retinal ganglion cells may be affected by displaced amacrine cells. (C) 2001 ISDN. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:10:02