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Titolo:
Role of Ca2+-stimulated adenylyl cyclases in LTP and memory formation
Autore:
Poser, S; Storm, DR;
Indirizzi:
Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Pharmacol, Seattle, WA 98195 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
fascicolo: 4, volume: 19, anno: 2001,
pagine: 387 - 394
SICI:
0736-5748(200107)19:4<387:ROCACI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; MEDIATED GENE-EXPRESSION; ACTIVATED PROTEIN-KINASE; NMDA RECEPTOR ACTIVATION; CAMP-RESPONSIVE ELEMENT; RAT HIPPOCAMPAL SLICES; DEPENDENT LATE-PHASE; C-FOS TRANSCRIPTION; MOSSY FIBER LTP; CYCLIC-AMP;
Keywords:
memory; cAMP/Ca2+ response element-binding protein; cAMP/Ca2+ response element; transcription; cAMP; Erk/Map kinase; adenylyl cyclase; calmodulin; neuroplasticity; calcium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Storm, DR Univ Washington, Dept Pharmacol, Hlth Sci Bldg,Mail Box 357750, Seattle, WA 98195 USA Univ Washington Hlth Sci Bldg,Mail Box 357750 SeattleWA USA 98195
Citazione:
S. Poser e D.R. Storm, "Role of Ca2+-stimulated adenylyl cyclases in LTP and memory formation", INT J DEV N, 19(4), 2001, pp. 387-394

Abstract

Studies with invertebrates and vertebrates have strongly implicated the CREB/CRE transcriptional pathway in long-term memory (LTM) and transcriptionally-dependent L-LTP. It is hypothesized that LTM and L-LTP are both dependent upon a Ca2+ signal generated through activation of NMDA receptors. This review discusses evidence that Ca2+ signals generated through activation ofNMDA receptors coactivate the Erk/MAP kinase and cAMP signal transduction pathways. It is hypothesized that activation of these two regulatory pathways increases the transcription of a family of genes through the CREB/CRE transcriptional pathway. Gene disruption studies have shown that Ca2+ activated adenylyl cyclases play a critical role in generating the cAMP signal required for LTM and L-LTP. Although cAMP may be required for several events in this complex signal transduction cascade, one of the major roles of cAMP may be to support nuclear translocation of Erk/MAP kinase in hippocampal neurons. (C) 2001 ISDN. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:58:55