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Titolo:
Family history of cancer and risk of esophageal and gastric cancers in theUnited States
Autore:
Dhillon, PK; Farrow, DC; Vaughan, TL; Chow, WH; Risch, HA; Gammon, MD; Mayne, ST; Stanford, JL; Schoenberg, JB; Ahsan, H; Dubrow, R; West, AB; Rotterdam, H; Blot, WJ; Fraumeni, JF;
Indirizzi:
Fred Hutchinson Canc Res Ctr, Program Epidemiol, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA Univ Washington, Sch Publ Hlth & Community Med, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Canc Epidemiol & Genet, Bethesda, MD 20892 USA Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 iol & Publ Hlth, New Haven, CT 06510 USA Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA , Dept Epidemiol, Chapel Hill, NC USA New Jersey Dept Hlth & Senior Serv, Off Canc Epidemiol, Trenton, NJ USA New Jersey Dept Hlth & Senior Serv Trenton NJ USA emiol, Trenton, NJ USA Columbia Univ, Joseph L Mailman Sch Publ Hlth, Div Epidemiol, New York, NYUSA Columbia Univ New York NY USA Publ Hlth, Div Epidemiol, New York, NYUSA Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 ed, Dept Pathol, New Haven, CT 06510 USA Columbia Univ, Coll Phys & Surg, Dept Pathol, New York, NY USA Columbia Univ New York NY USA Phys & Surg, Dept Pathol, New York, NY USA Int Epidemiol Inst, Rockville, MD USA Int Epidemiol Inst Rockville MD USA nt Epidemiol Inst, Rockville, MD USA
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 1, volume: 93, anno: 2001,
pagine: 148 - 152
SICI:
0020-7136(20010701)93:1<148:FHOCAR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; STOMACH-CANCER; SOCIOECONOMIC-FACTORS; HELICOBACTER-PYLORI; COLORECTAL-CANCER; SHANXI-PROVINCE; ADENOCARCINOMA; TOBACCO; CARDIA; ALCOHOL;
Keywords:
esophageal neoplasm; stomach neoplasm; case-control study; family history; United States;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Farrow, DC Fred Hutchinson Canc Res Ctr, Program Epidemiol, 1100 Fairview Ave N,POB 19024,MP-474, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr 1100 Fairview Ave N,POB 19024,MP-474 Seattle WA USA 98109
Citazione:
P.K. Dhillon et al., "Family history of cancer and risk of esophageal and gastric cancers in theUnited States", INT J CANC, 93(1), 2001, pp. 148-152

Abstract

The worldwide rates for histology- and subsite-specific types of esophageal and gastric cancer reveal strikingly divergent patterns. The contributionof environmental and genetic factors has been explored in several high-incidence areas, but data on genetic influences are scarce for Western countries. Using data from a multicenter, population-based, case-control study on 1,143 cases and 695 controls in the United States, we evaluated whether a family history of digestive or other cancers was associated with an increased risk of esophageal adenocarcinoma (n = 293), esophageal squamous cell carcinoma (n = 221), gastric cardia adenocarcinoma(n = 261) or non-cardia gastric adenocarcinoma (n = 368). After adjusting for other risk factors, individuals reporting a family history of digestive cancers experienced no increased risk of either type of esophageal cancer but they were prone to adenocarcinomas of the gastric cardia [odds ratio (OR) = 1.34, 95% confidence interval (CI) 0.91-1.97] and non-cardia segments (OR = 1.46, 95% CI 1.03-2.08). This familial tendency, particularly for non-cardia gastric tumors, was largely explained by an association with family history of stomach cancer (OR = 2.52, 95% CI 1.50-4.23), In addition, family history of breast cancer was associated with increased risks of esophageal adenocarcinoma (OR = 1.74,95% CI 1.07-2.83) and non-cardia gastric adenocarcinoma (OR = 1.76, 95% CI1.09-2.82). Also seen were non-significant familial associations of esophageal squamous-cell cancer with prostate cancer as well as non-cardia gastric cancer with leukemia and brain tumors, though these relationships must beinterpreted with caution. Our data point to the role of familial susceptibility to gastric cancer, but not to any form of esophageal cancer, in the United States. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 26/09/20 alle ore 13:51:30