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Titolo:
Evaluation of two in vitro pharmacodynamic simulation models: Microfiltration versus centrifugation-filtration
Autore:
Alou, L; Sevillano, D; Bugella, JH; Fuentes, F; Gomez-Lus, ML; Prieto, J;
Indirizzi:
Univ Complutense Madrid, Dept Microbiol, Sch Med, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 Med, E-28040 Madrid, Spain
Titolo Testata:
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
fascicolo: 5, volume: 17, anno: 2001,
pagine: 365 - 370
SICI:
0924-8579(200105)17:5<365:EOTIVP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO; STREPTOCOCCUS-PNEUMONIAE; HAEMOPHILUS-INFLUENZAE; BACTERICIDAL ACTIVITY; PHYSIOLOGICAL CONCENTRATIONS; PHARMACOKINETICS; CIPROFLOXACIN; CLARITHROMYCIN; TROVAFLOXACIN; AMOXICILLIN;
Keywords:
pharmacodynamics; simulation models; in vitro activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Prieto, J Univ Complutense Madrid, Dept Microbiol, Sch Med, Av ComplutenseS-N, E-28040 Madrid, Spain Univ Complutense Madrid Av Complutense S-N Madrid Spain E-28040
Citazione:
L. Alou et al., "Evaluation of two in vitro pharmacodynamic simulation models: Microfiltration versus centrifugation-filtration", INT J ANT A, 17(5), 2001, pp. 365-370

Abstract

Pharmacodynamic in vitro models that simulate serum antimicrobial concentrations provide more information about the activity of an antibiotic than MICs or traditional time-kill methods. The aim of this study was to compare two pharmacodynamic simulation models using ATCC strains of five different species and five antibiotics. In the first model (Centriprep-10 system), a filtration-centrifugation process was used to eliminate the antibiotic; in the second model (microfiltration system) no centrifugation was necessary. The antibiotic concentrations tested were similar to those in serum after normal doses of cefuroxime, clarithromycin, ciprofloxacin, gentamicin and cefotaxime. No significant differences were observed in the killing rates between the models except in the case of Haemophilus influenzae and cefotaxime. The new microfiltration model had the following advantages: lack of the carry-over effect, the absence of centrifugation that could damage bacteria and the possibility of increasing the number of incubation periods to give abetter fit of the kinetic profile of man. (C) 2001 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:36:09