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Titolo:
Fc epsilon RI-mediated activation of transcription factors in antigen-presenting coils
Autore:
Kraft, S; Bieber, T;
Indirizzi:
Univ Bonn, Dept Dermatol, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 onn, Dept Dermatol, D-53105 Bonn, Germany
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 1, volume: 125, anno: 2001,
pagine: 9 - 15
SICI:
1018-2438(200105)125:1<9:FERAOT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; EPIDERMAL LANGERHANS CELLS; HIGH-AFFINITY RECEPTOR; DENDRITIC CELLS; NUCLEAR-FACTOR; MAST-CELLS; T-CELLS; ALLERGEN PRESENTATION; ATOPIC-DERMATITIS; HUMAN MONOCYTES;
Keywords:
IgE receptor; antigen-presenting cells; NFAT; NF-kappa B; transcription;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Kraft, S Univ Bonn, Dept Dermatol, Sigmund Freud Str 25, D-53105 Bonn, Germany Univ Bonn Sigmund Freud Str 25 Bonn Germany D-53105 onn, Germany
Citazione:
S. Kraft e T. Bieber, "Fc epsilon RI-mediated activation of transcription factors in antigen-presenting coils", INT A AL IM, 125(1), 2001, pp. 9-15

Abstract

Professional antigen-presenting cells (APC) such as monocytes and dendritic cells (DC) bearing high-affinity IgE receptors (Fc epsilon RI) efficiently present IgE-bound antigens to T cells. Fc epsilon RI expression is upregulated on APC from atopic donors, especially in inflamed tissues. These datasuggest a pathophysiological concept of an IgE-mediated delayed-type hypersensitivity reaction in atopic diseases. However, FceRI ligation also leadsto the synthesis of proinflammatory cytokines and other molecules involvedin inflammatory reactions. The investigation of transcription factors mediating these effects has only recently commenced. In general, members of theNF-KB family are known to regulate APC function and differentiation, with the RelB subunit being especially important in DC generation. In addition, Ikaros and PU.1 have also been shown to be essential factors for DC differentiation, whereas Oct-2 is upregulated by differentiation towards macrophages. Recently, Fc epsilon RI has been demonstrated to induce NF-KB activation via I kappaB-alpha serine phosphorylation and degradation in monocytes and DC. Inhibitors of NF-kappaB activation such as N-acetylcysteine or N-tosyl-L-phenylalanine chloromethyl ketone can suppress Fc epsilon RI-induced TNF-alpha and MCP-1 release. Interestingly, in human epidermal Langerhans' cells (LC), NF-kappaB activation can only be observed when large amounts of Fc epsilon RI are present. In addition, the composition of NF-kappaB complexes differs between monocytes, monocyte-derived DC and LC, suggesting a celltype-specific regulation. Moreover, the transcription factor NFAT is induced upon Fc epsilon RI ligation in human APC, The elucidation of further transcription factors involved in Fc epsilon RI signaling in APC should contribute to the employment of new inhibition strategies for the treatment of atopic and other inflammatory diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:20:15