Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Sensitisation of group III articular afferents to mechanical stimuli by substance P
Autore:
Herbert, MK; Schmidt, RE;
Indirizzi:
Inst Physiol, D-97070 Wurzburg, Germany Inst Physiol Wurzburg Germany D-97070 Physiol, D-97070 Wurzburg, Germany Klin Anaesthesiol, D-97080 Wurzburg, Germany Klin Anaesthesiol Wurzburg Germany D-97080 ol, D-97080 Wurzburg, Germany
Titolo Testata:
INFLAMMATION RESEARCH
fascicolo: 5, volume: 50, anno: 2001,
pagine: 275 - 282
SICI:
1023-3830(200105)50:5<275:SOGIAA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; INFLAMED KNEE JOINTS; DORSAL-ROOT GANGLIA; SYNOVIAL-FLUID; EXPERIMENTAL ARTHRITIS; RHEUMATOID-ARTHRITIS; TEMPOROMANDIBULAR-JOINT; INFLAMMATORY MEDIATORS; ANTIBODY MICROPROBES; HISTAMINE-RELEASE;
Keywords:
substance P; articular afferent; nociceptor; knee joint;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Schmidt, RE Inst Physiol, Rontgenring 9, D-97070 Wurzburg, Germany Inst Physiol Rontgenring 9 Wurzburg Germany D-97070 , Germany
Citazione:
M.K. Herbert e R.E. Schmidt, "Sensitisation of group III articular afferents to mechanical stimuli by substance P", INFLAMM RES, 50(5), 2001, pp. 275-282

Abstract

Objective: To examine the excitatory and sensitising effects of substance P (SP) on articular afferents in normal and acutely inflamed cat knee joints. Materials and methods: In anesthetised cats recordings were made from 15 group III (conduction velocity 2.5-20 m/s) and 25 group IV afferent units (conduction velocity < 2.5 m/s) of the medial articular nerve of normal and acutely inflamed knee joints. SP (10 and 100 mug) was administered close-arterially. Results: SP at doses of 10 mug and 100 mug activated less than 50 % of both group III and group IV units. The proportion of SP-positive units was significantly higher in inflamed(10 of 21) than in normal joints (2 of 18). SPinduced activity in initially silent units or increased ongoing activity after latencies varying from 2 s to 5 min. The SP-evoked activity had an irregular pattern, a variable duration, and was not related to the dose injected. Bolus injections of SP (100 mug) sensitised group III articular afferents but not group TV units to noxious movements of the joint, regardless whether the units were from normal or acutely inflamed joints. The responses to innocuous movements were not influenced by SP. Group III units, initiallynot activated by any movement, displayed vigorous discharges to noxious movements after close-arterial SP. In 3 group III units tested, the SP-induced augmentation of responses to noxious movements was not mimicked by close-arterial injection of histamine (3.3 mug). Conclusions: It is concluded that SP contributes to the sensitisation of asubpopulation of high-threshold articular afferents. Thus this neuronal mediator released peripherally in response to an injury or acute inflammationcauses considerable changes in the mechanosensitivity of this subpopulation of nociceptive joint afferents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 05:27:38