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Titolo:
Hypotensive and natriuretic actions of adrenomedullin in subjects with chronic renal impairment
Autore:
McGregor, DO; Troughton, RW; Frampton, C; Lynn, KL; Yandle, T; Richards, AM; Nicholls, MG;
Indirizzi:
Christchurch Hosp, Dept Nephrol, Christchurch, New Zealand Christchurch Hosp Christchurch New Zealand l, Christchurch, New Zealand Christchurch Hosp, Cardioendocrine Res Grp, Christchurch, New Zealand Christchurch Hosp Christchurch New Zealand p, Christchurch, New Zealand
Titolo Testata:
HYPERTENSION
fascicolo: 5, volume: 37, anno: 2001,
pagine: 1279 - 1284
SICI:
0194-911X(200105)37:5<1279:HANAOA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT MESANGIAL CELLS; INCREASED PLASMA ADRENOMEDULLIN; HEART-FAILURE; PEPTIDE; HYPERTENSION; MITOGENESIS; PROTEINURIA; NEPHROPATHY; HOMEOSTASIS; INFUSION;
Keywords:
adrenomedullin; renal disease; immunoglobulins; proteinuria; renin; angiotensin II; sympathetic nervous system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: McGregor, DO Christchurch Hosp, Dept Nephrol, Private Bag 4710, Christchurch, New Zealand Christchurch Hosp Private Bag 4710 Christchurch New Zealand
Citazione:
D.O. McGregor et al., "Hypotensive and natriuretic actions of adrenomedullin in subjects with chronic renal impairment", HYPERTENSIO, 37(5), 2001, pp. 1279-1284

Abstract

Plasma levels of adrenomedullin are increased in chronic renal failure. The significance of this finding is uncertain, because the biological effectsof adrenomedullin in renal impairment are unknown. Therefore, we studied the effects of adrenomedullin infusion in subjects with chronic renal impairment. Eight males with IgA nephropathy and plasma creatinine of 0.19 +/-0.03 mmol/L (mean +/- SEM) were studied in a vehicle-controlled crossover design, Each subject was studied twice; subjects were administered either adrenomedullin at a low dose and then a high dose (2.9 and 5.8 pmol/kg per minute, respectively, for 2 hours each) or a 4-hour vehicle control (Hemaccel), in random order, on day 4 of controlled metabolic diets. Adrenomedullin infusion achieved plasma adrenomedullin concentrations in the pathophysiological range after the low (31.2 +/-5.1 pmol/L) and high (47.4 +/-4.3 pmol/L) dose, and plasma cAMP was increased. Compared with vehicle control, high-dose adrenomedullin increased peak heart rate (+21.7 +/-3.3 bpm, P<0.01) and cardiac output (+2.9<plus/minus>0.2 L/min, P<0.01) and lowered both systolicand diastolic blood pressures by >10 mm Hg (P<0.05), Plasma renin activity, angiotensin II, and norepinephrine increased by up to 50% above baseline levels (P<0.05 for all), whereas aldosterone and epinephrine were unchanged. Urinary volume and sodium excretion increased significantly (P<0.05) withlow-dose adrenomedullin, whereas creatinine clearance was stable, and proteinuria tended to decrease. In subjects with chronic renal impairment due to IgA nephropathy, adrenomedullin infusion lowered blood pressure, stimulated sympathetic activity and renin release, and caused diuresis and natriuresis. Adrenomedullin may have a role in modulating blood pressure and kidneyfunction in renal disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 06:33:50