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Titolo:
Cardiovascular mortality in hypertensive men according to presence of associated risk factors
Autore:
Thomas, F; Rudnichi, A; Bacri, AM; Bean, K; Guize, L; Benetos, A;
Indirizzi:
Ctr IPC, F-75784 Paris 16, France Ctr IPC Paris France 16Ctr IPC, F-75784 Paris 16, France
Titolo Testata:
HYPERTENSION
fascicolo: 5, volume: 37, anno: 2001,
pagine: 1256 - 1261
SICI:
0194-911X(200105)37:5<1256:CMIHMA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; BLOOD-PRESSURE; PULSE PRESSURE; CHOLESTEROL; POPULATION; PREDICTOR; EVENTS; TRIAL; AGE;
Keywords:
hypertension, essential; risk factors; blood pressure; mortality;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Benetos, A Ctr IPC, 6-14 Rue La Perouse, F-75784 Paris 16, France Ctr IPC 6-14 Rue La Perouse Paris France 16 4 Paris 16, France
Citazione:
F. Thomas et al., "Cardiovascular mortality in hypertensive men according to presence of associated risk factors", HYPERTENSIO, 37(5), 2001, pp. 1256-1261

Abstract

To evaluate the risk of cardiovascular disease (CVD) mortality in hypertensive men according to the presence of associated risk factors (ARFs). The population was composed of 29 640 normotensive men without ARFs (reference group) and 60 343 hypertensive men (with and without ARFs) who had a standard health checkup at the Centre d'Investigations Preventives et Cliniques between 1978 and 1988. Mortality data for a mean period of 14 years were analyzed. The following ARFs were considered: total cholesterol greater than orequal to2.5 g/L, personal history of diabetes, smoking (current smokers), body mass index >28 kg/m(2), and heart rate >80 bpm. CVD risk related to the presence of isolated hypertension (assessed in hypertensive subjects without ARFs versus the reference group) increased linearly from 15% at the ageof 30 years to 134% at the age of 80 years. In hypertensive subjects, one additional ARF increased CVD risk by 56% (47% to 65%, P<0.01) in younger subjects but only by 4% (-8% to 17%, P=NS) in older subjects. The role of hypercholesterolemia and tobacco smoking in CVD mortality was significantly higher in hypertensive subjects aged <55 years than in hypertensive subjects aged greater than or equal to 55 years (P<0.01), whereas the roles of tachycardia and obesity were not affected by age. In younger hypertensive subjects, evaluation of CVD risk and therapeutic strategies should target ARFs. In older subjects, the presence of high blood pressure levels seems to be the major determinant of CVD risk.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:56:35