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Titolo:
Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
Autore:
Laurent, S; Boutouyrie, P; Asmar, R; Gautier, I; Laloux, B; Guize, L; Ducimetiere, P; Benetos, A;
Indirizzi:
Broussais Hosp, Dept Pharmacol, Paris, France Broussais Hosp Paris France oussais Hosp, Dept Pharmacol, Paris, France Broussais Hosp, INSERM, U337, Paris, France Broussais Hosp Paris FranceBroussais Hosp, INSERM, U337, Paris, France ICV, Inst Cardiovasc, Paris, France ICV Paris FranceICV, Inst Cardiovasc, Paris, France INSERM, U258, Paris, France INSERM Paris FranceINSERM, U258, Paris, France
Titolo Testata:
HYPERTENSION
fascicolo: 5, volume: 37, anno: 2001,
pagine: 1236 - 1241
SICI:
0194-911X(200105)37:5<1236:ASIAIP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULSE-WAVE VELOCITY; STAGE RENAL-DISEASE; BLOOD-PRESSURE; ARTERIAL DISTENSIBILITY; MYOCARDIAL-INFARCTION; RISK; ATHEROSCLEROSIS; DETERMINANTS; EVENTS; STROKE;
Keywords:
arterial stiffness; cardiovascular diseases; mortality; hypertension, essential; pulse wave velocity; distensibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Laurent, S Hop Europeen Georges Pompidou, Serv Pharmacol, 20 Rue Leblanc, F-75015 Paris, France Hop Europeen Georges Pompidou 20 Rue Leblanc Paris France F-75015
Citazione:
S. Laurent et al., "Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients", HYPERTENSIO, 37(5), 2001, pp. 1236-1241

Abstract

Although various studies reported that pulse pressure, an indirect index of arterial stiffening, was an independent risk factor for mortality, a direct relationship between arterial stiffness and all-cause and cardiovascularmortality remained to be established in patients with essential hypertension. A cohort of 1980 essential hypertensive patients who attended the outpatient hypertension clinic of Broussais Hospital between 1980 and 1996 and who had a measurement of arterial stiffness was studied. At entry, aortic stiffness was assessed from the measurement of carotid-femoral pulse-wave velocity (PWV). A logistic regression model was used to estimate the relative risk of all-cause and cardiovascular deaths. Selection of classic risk factors for adjustment of PWV was based on their influence on mortality in thiscohort in univariate analysis. Mean age at entry was 50 +/- 13 years (mean+/- SD). During an average follow-up of 112 +/- 53 months, 107 fatal events occurred. Among them, 46 were of cardiovascular origin. PWV was significantly associated with all-cause and cardiovascular mortality in a univariatemodel of logistic regression analysis (odds ratio for 5 m/s PWV was 2.14 [95% confidence interval, 1.71 to 2.67, P<0.0001] and 2.35 [95% confidence interval, 1.76 to 3.14, P<0.0001], respectively). In multivariate models of logistic regression analysis, PWV was significantly associated with all-cause and cardiovascular mortality, independent of previous cardiovascular diseases, age, and diabetes. By contrast, pulse pressure was not significantlyand independently associated to mortality. This study provides the first direct evidence that aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with essential hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:28:58