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Titolo:
Automation in genotyping of single nucleotide polymorphisms
Autore:
Gut, IG;
Indirizzi:
Ctr Natl Genotypage, F-91057 Evry, France Ctr Natl Genotypage Evry France F-91057 Genotypage, F-91057 Evry, France
Titolo Testata:
HUMAN MUTATION
fascicolo: 6, volume: 17, anno: 2001,
pagine: 475 - 492
SICI:
1059-7794(2001)17:6<475:AIGOSN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOF MASS-SPECTROMETRY; OLIGONUCLEOTIDE LIGATION ASSAY; DNA DIAGNOSTIC METHOD; PRIMER EXTENSION; POINT MUTATIONS; MOLECULAR BEACONS; GENETIC-ANALYSIS; ENERGY-TRANSFER; FLOW-CYTOMETRY; PADLOCK PROBES;
Keywords:
SNP; automation; genotyping; DNA analysis; mutation detection; variation; robotics; arrays; microarrays; microspheres; mass spectrometry;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Gut, IG Ctr Natl Genotypage, Batiment G2,2 Rue Gaston Cremieux,CP 5721, F-91057 Evry, France Ctr Natl Genotypage Batiment G2,2 Rue Gaston Cremieux,CP5721 Evry France F-91057
Citazione:
I.G. Gut, "Automation in genotyping of single nucleotide polymorphisms", HUM MUTAT, 17(6), 2001, pp. 475-492

Abstract

Automation for genotyping of single nucleotide polymorphisms (SNPs) can besplit into the automation of the sample preparation and the automation of the analysis technology. SNP genotyping methods are reviewed and solutions for their automation discussed. A panacea for SNP genotyping does not exist. Different scientific questions require adapted solutions. The choice of atechnology for SNP genotyping depends on whether few different SNPs are tobe genotyped in many individuals, or many different SNPs are to be genotyped in few individuals. The requirements of throughput and the ease of establishing an SNP genotyping operation are important, as well as the degree ofintegration. The potential and state-of the art of different solutions areoutlined. Hum Mutat 17:475-492, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:04:03