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Titolo:
Effect of leptin on insulin, glugacon and somatostatin secretion in the perfused rat pancreas
Autore:
Silvestre, RA; Rodriguez-Gallardo, J; Egido, EM; Marco, J;
Indirizzi:
Univ Autonoma Madrid, Clin Puerta Hierro, Madrid 28035, Spain Univ Autonoma Madrid Madrid Spain 28035 erta Hierro, Madrid 28035, Spain Univ Autonoma Madrid, Dept Physiol, Madrid 28035, Spain Univ Autonoma Madrid Madrid Spain 28035 ept Physiol, Madrid 28035, Spain
Titolo Testata:
HORMONE AND METABOLIC RESEARCH
fascicolo: 4, volume: 33, anno: 2001,
pagine: 207 - 212
SICI:
0018-5043(200104)33:4<207:EOLOIG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; HUMAN ISLETS; IN-VIVO; CELLS; EXPRESSION; STIMULATION; INHIBITION; LANGERHANS; GLUCAGON; RELEASE;
Keywords:
rat pancreas; leptin; insulin; glucagon; somatostatin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Marco, J Univ Autonoma Madrid, Clin Puerta Hierro, San Martin Porres 4, Madrid 28035, Spain Univ Autonoma Madrid San Martin Porres 4 Madrid Spain 28035 pain
Citazione:
R.A. Silvestre et al., "Effect of leptin on insulin, glugacon and somatostatin secretion in the perfused rat pancreas", HORMONE MET, 33(4), 2001, pp. 207-212

Abstract

We have investigated the effect of rat leptin as well as the 22-56 fragment of this molecule on pancreatic hormone secretion in the perfused rat pancreas. In pancreases from fed rats, leptin failed to alter the insulin secretion elicited by glucose, arginine or tolbutamide, but inhibited the insulin response to both CCK-8 and carbachol, secretagogues known to act on the B-cell by increasing phospholipid turnover. This insulinostatic effect was also observed with the 22-56 leptin fragment, In pancreases obtained from 24-hour fasted rats, no effect of leptin on carbachol-induced insulin output was found, perhaps as a consequence of depressed B-cell phospholipid metabolism. Leptin did not influence glucagon or somatostatin release. Our results do not support the concept of leptin as a major regulator of B-cell function. Leptin inhibition of carbachol-induced insulin output might reflect a restraining effect of this peptide on the cholinergic stimulation of insulin release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:07:00