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Titolo:
CP2289, A NEW 5-HT3 RECEPTOR-LIGAND - AGONISTIC ACTIVITIES ON GASTROENTERIC MOTILITY
Autore:
SATO Y; IMAI M; AMANO K; IWAMATSU K; KONNO F; KURATA Y; SAKAKIBARA S; HACHISU M; IZUMI M; MATSUKI N; SAITO H;
Indirizzi:
MEIJI SEIKA KAISHA LTD,PHARMACEUT RES CTR,KOHOKU KU,760 MOROOKA CHO YOKOHAMA KANAGAWA 222 JAPAN UNIV TOKYO,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,BUNKYO KU TOKYO 113JAPAN
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 7, volume: 20, anno: 1997,
pagine: 752 - 755
SICI:
0918-6158(1997)20:7<752:CAN5R->2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUNCUS-MURINUS; INDUCED EMESIS; ANTAGONISTS; IDENTIFICATION; BLOCKADE;
Keywords:
CP2289; 5-HT3 RECEPTOR; AGONIST; ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
Y. Sato et al., "CP2289, A NEW 5-HT3 RECEPTOR-LIGAND - AGONISTIC ACTIVITIES ON GASTROENTERIC MOTILITY", Biological & pharmaceutical bulletin, 20(7), 1997, pp. 752-755

Abstract

A new 5-HT3 receptor ligand, CP2289, was synthesized and pharmacologically tested. Although CP2289 inhibited the Bezold-Jarisch reflex, it contracted the excised ileal muscle of mice, rats and guinea pigs. This response may reheat a partial agonist character of CP2289 in the gut. In vivo antiemetic and gastric emptying tests gave similar results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:56:36