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Titolo:
Interleukin-6 and C-reactive protein serum levels in sepsis-related fatalities during the early postmortem period
Autore:
Tsokos, M; Reichelt, U; Jung, R; Nierhaus, A; Puschel, K;
Indirizzi:
Univ Hamburg, Inst Legal Med, D-22529 Hamburg, Germany Univ Hamburg Hamburg Germany D-22529 Legal Med, D-22529 Hamburg, Germany Univ Hamburg, Hosp Eppendorf, Dept Clin Chem, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 Clin Chem, D-20246 Hamburg, Germany Univ Hamburg, Hosp Eppendorf, Dept Anesthesiol, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 esthesiol, D-20246 Hamburg, Germany
Titolo Testata:
FORENSIC SCIENCE INTERNATIONAL
fascicolo: 1, volume: 119, anno: 2001,
pagine: 47 - 56
SICI:
0379-0738(20010601)119:1<47:IACPSL>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY RESPONSE SYNDROME; ACUTE-PHASE PROTEINS; SEPTIC SHOCK; PERIPHERAL-BLOOD; IL-6 PRODUCTION; SIRS; CYTOKINES; DEFINITION; CORRELATE; INFECTION;
Keywords:
interleukin-4; IL-6; C-reactive protein; CRP; sepsis; systemic inflammatory response syndrome; SIRS; burn injury; postmortem biochemistry; postmortem sepsis diagnostics; postmortem markers of sepsis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Tsokos, M Univ Hamburg, Inst Legal Med, Butenfeld 34, D-22529 Hamburg, Germany Univ Hamburg Butenfeld 34 Hamburg Germany D-22529 burg, Germany
Citazione:
M. Tsokos et al., "Interleukin-6 and C-reactive protein serum levels in sepsis-related fatalities during the early postmortem period", FOREN SCI I, 119(1), 2001, pp. 47-56

Abstract

Postmortem interleukin-6 (IL-6) and C-reactive protein (CRP) serum levels were investigated prospectively in sepsis-related fatalities and non-septicfatalities by using a a linear regression model. At least three blood samples were collected between 0.3 and 139 h postmortem from sepsis-related Fatalities (n = 8) and non-septic fatalities (n = 16). In addition, one antemortem blood sample was collected shortly before death from the septic patients. Antemortem and postmortem IL-6 and CRP levels were highly elevated in all individuals included in the sepsis group. An excessive postmortem increase of IL-6 serum levels associated with progressive time after death was observed in five out of the eight septic patients. Both, IL-6 and CRP serum concentrations seem to be suitable biochemical postmortem markers of sepsis. The determination of IL-6 serum levels above 1500 pg/ml in peripheral venous blood obtained in the early postmortem interval can be considered as a diagnostic hint towards an underlying septic condition. A more precise postmortem discrimination between sepsis and nonseptic underlying causes of death is provided by the postmortem measurement of serum CRP in peripheral venous blood: on condition that at least two postmortem CRP values have been determined at different time points postmortem, the CRP level of a deceased at the time of death can be calculated by using linear regression analysis. When assessing postmortem IL-6 and CRP concentrations as biochemical postmortem markers of sepsis, various clinical conditions, such as a preceding trauma or burn injury going along with elevated IL-6 and/or CRP levels prior to death as a result of the systemic inflammatory response syndrome (SIRS) should be taken into consideration, thus adding relevant information for the practical interpretation of the results. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:09:54