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Titolo:
Green tea and the metabolism of 2-amino-3-methylimidazo [4,5-f]quinoline in F344 rats
Autore:
Embola, CW; Weisburger, MC; Weisburger, JH;
Indirizzi:
Amer Hlth Fdn, Valhalla, NY 10595 USA Amer Hlth Fdn Valhalla NY USA 10595Amer Hlth Fdn, Valhalla, NY 10595 USA Case Western Reserve Univ, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA New York Med Coll, Dept Pathol, Valhalla, NY USA New York Med Coll Valhalla NY USA ed Coll, Dept Pathol, Valhalla, NY USA
Titolo Testata:
FOOD AND CHEMICAL TOXICOLOGY
fascicolo: 6, volume: 39, anno: 2001,
pagine: 629 - 633
SICI:
0278-6915(200106)39:6<629:GTATMO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOD MUTAGEN 2-AMINO-3-METHYLIMIDAZO<4,5-F>QUINOLINE; CARCINOGENICITY; CONSUMPTION; POLYPHENOLS; HEALTH; ACID;
Keywords:
green tea; heterocyclic amines; 2-amino-3-methylimidazo[4 ; 5-f]quinoline; IQ; metabolism; detoxification; glucuronides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Weisburger, JH Amer Hlth Fdn, 1 Dana Rd, Valhalla, NY 10595 USA Amer Hlth Fdn 1 Dana Rd Valhalla NY USA 10595 NY 10595 USA
Citazione:
C.W. Embola et al., "Green tea and the metabolism of 2-amino-3-methylimidazo [4,5-f]quinoline in F344 rats", FOOD CHEM T, 39(6), 2001, pp. 629-633

Abstract

The effects of green tea intake on the metabolism of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in the rat was studied. IQ belongs to a new class of mutagens and carcinogens, heterocyclic arylamines, formed during cooking through browning meats and fish, thus, in the food chain of most non-vegetarians. Ten adult male and female Fischer 344 rats were placed on a 2% solution of green tea and 10 control rats were on water for 6 weeks. Then, animals were administered a single dose of 40 mg/kg body weight of [2-C-14]IQ byoral gavage. Twenty-four hour urine samples were collected and metaboliteswere separated by HPLC and quantitated by scintillation counting. Two minor and three major metabolites were isolated, including, small quantities ofIQ itself. The rats on tea showed significant differences (P < 0.05) in the recovery of the three major metabolites, namely, IQ-sulfamate, IQ-5-O-sulfate, and IQ-5-O-glucuronide, respectively. Green tea, therefore, influences the manner in which the food carcinogen IQ is metabolized and excreted inurine. Formation of glucuronides, increased by green tea, represent a key means of detoxification of the heterocyclic amine, IQ. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:08:48