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Titolo:
Hepatocarcinogenesis inhibition by caffeine in ACI rats treated with 2-acetylaminofluorene
Autore:
Hosaka, S; Kawa, S; Aoki, Y; Tanaka, E; Yoshizawa, K; Karasawa, Y; Hosaka, N;
Indirizzi:
Shinshu Univ, Sch Med, Dept Internal Med 2, Nagano 3908621, Japan Shinshu Univ Nagano Japan 3908621 Internal Med 2, Nagano 3908621, Japan Shinshu Univ, Sch Med, Dept Lab Med, Nagano 3908621, Japan Shinshu Univ Nagano Japan 3908621 d, Dept Lab Med, Nagano 3908621, Japan
Titolo Testata:
FOOD AND CHEMICAL TOXICOLOGY
fascicolo: 6, volume: 39, anno: 2001,
pagine: 557 - 561
SICI:
0278-6915(200106)39:6<557:HIBCIA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GREEN TEA; PANCREATIC CARCINOGENESIS; CHEMICAL CARCINOGENESIS; IMPORTANT CONSTITUENT; LUNG TUMORIGENESIS; CELL-DEATH; SKH-1 MICE; BLACK TEA; A/J MICE; APOPTOSIS;
Keywords:
caffeine; hepatocarcinogenesis inhibition; ACI rats; 2-acetylaminofluorene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Hosaka, S Shinshu Univ, Sch Med, Dept Internal Med 2, 3-1-1 Asahi Matsumoto, Nagano 3908621, Japan Shinshu Univ 3-1-1 Asahi Matsumoto Nagano Japan 3908621 , Japan
Citazione:
S. Hosaka et al., "Hepatocarcinogenesis inhibition by caffeine in ACI rats treated with 2-acetylaminofluorene", FOOD CHEM T, 39(6), 2001, pp. 557-561

Abstract

The inhibitory effects of caffeine have been demonstrated on the development of various organs in animals. The purpose of the present study was to examine the inhibitory effect of caffeine on hepatocarcinogenesis and to determine the responsive dose of caffeine on hepatocarcinogenesis in young maleACI rats. Animals given a diet containing 2-acetylaminofluorene (2-AAF) for 12 weeks and then a basal diet and tap water containing caffeine for 18 weeks showed statistically significant decreases in the incidence. multiplicity (the number of hepatic tumors per rat) and histological grade compared with rats fed a diet containing carcinogen for 12 weeks followed by tap water alone. Dose-dependent inhibition of hepatocarcinogenesis by caffeine a ns also seen. The inhibitory effect of caffeine on hepatocarcinogenesis in rats was found when caffeine was administered during the initiation phase. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:29:04