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Titolo:
Beneficial effects of some vitamins and calcium on fluoride and aluminium toxicity on gastrocnemius muscle and liver of male mice
Autore:
Chinoy, NJ; Memon, MR;
Indirizzi:
Gujarat Univ, Sch Sci, Dept Zool, Reprod Endocrinol & Toxicol Unit, Ahmedabad 380009, Gujarat, India Gujarat Univ Ahmedabad Gujarat India 380009 edabad 380009, Gujarat, India
Titolo Testata:
FLUORIDE
fascicolo: 1, volume: 34, anno: 2001,
pagine: 21 - 33
SICI:
0015-4725(200102)34:1<21:BEOSVA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASCORBIC-ACID; DEVELOPMENTAL TOXICITY; REPRODUCTIVE FUNCTIONS; MALE-RATS; CARBOHYDRATE; METABOLISM; REVERSAL;
Keywords:
aluminium chloride; ascorbic acid antidote; calcium antidote; cholinesterase activity; fluoride toxicity; gastrocnemius muscle; glycogen accumulation; liver; male mice; oxidative metabolisms; protein alteration; phosphorylase inhibition; serum transaminases; sodium fluoride; toxicity reversal; vitamin E antidote;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Chinoy, NJ Gujarat Univ, Sch Sci, Dept Zool, Reprod Endocrinol & Toxicol Unit, Ahmedabad 380009, Gujarat, India Gujarat Univ Ahmedabad Gujarat India380009 09, Gujarat, India
Citazione:
N.J. Chinoy e M.R. Memon, "Beneficial effects of some vitamins and calcium on fluoride and aluminium toxicity on gastrocnemius muscle and liver of male mice", FLUORIDE, 34(1), 2001, pp. 21-33

Abstract

Treatment of male mice (Mus musculus) with sodium fluoride (NaF, 10 mg/kg body weight), alone or in combination with aluminium chloride (AlCl3, 200 mg/kg body weight), was investigated for its effects on gastrocnemius muscleand liver. Recovery after one-month withdrawal of treatment and responses to some antidotes, viz calcium, ascorbic acid, and vitamin E administered alone or in combination were also studied. NaF alone or in combination with AlCl3 caused a significant decrease in protein levels and activity of succinate dehydrogenase (SDH) in liver and gastrocnemius muscle, thereby indicating altered protein and oxidative metabolisms in these tissues. Cholinesterase activity declined significantly with all the treatments in both tissues, probably affecting the synaptic transmission due to altered acetylcholinerelease or metabolism and altering muscle contraction. All three treatments caused changes in liver function as shown by a significant increase in serum transminases, accumulation of glycogen and inhibition of phosphorylase activity thereby indicating that carbohydrate metabolism was affected. Similar changes occurred in muscle tissue. Gastrocnemius muscle and liver were therefore affected by sodium fluoride, aluminium chloride and in combination. Recovery was not significant on withdrawal of NaF + AlCl3 treatment. However, all three antidotes brought about significant recovery in the organs studied, Individually, ascorbic acid was the most beneficial in bringing about pronounced recovery. Thus, intoxication induced by sodium fluoride and aluminium chloride is transient and reversible.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:28:35