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Titolo:
Relief of vasomotor symptoms and vaginal atrophy with lower doses of conjugated equine estrogens and medroxyprogesterone acetate
Autore:
Utian, WH; Shoupe, D; Bachmann, G; Pinkerton, JV; Pickar, JH;
Indirizzi:
Case Western Reserve Univ, Dept Obstet & Gynecol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ So Calif, Dept Obstet & Gynecol, Keck Sch Med, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Sch Med, Los Angeles, CA 90089 USA Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Obstet & Gynecol, New Brunswick, NJ USA Univ Med & Dent New Jersey New Brunswick NJ USA l, New Brunswick, NJ USA Univ Virginia, Hlth Sci Ctr, Dept Obstet & Gynecol, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Wyeth Ayerst Res, Philadelphia, PA USA Wyeth Ayerst Res Philadelphia PA USA th Ayerst Res, Philadelphia, PA USA
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 6, volume: 75, anno: 2001,
pagine: 1065 - 1079
SICI:
0015-0282(200106)75:6<1065:ROVSAV>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTRADIOL TRANSDERMAL SYSTEM; HORMONE REPLACEMENT THERAPY; POSTMENOPAUSAL WOMEN; EFFICACY; PLACEBO; BONE; SAFETY; 7-DAY; HRT;
Keywords:
conjugated equine estrogens (CEE); medroxyprogesterone acetate (MPA); lower doses; vasomotor symptoms; Women's HOPE study; hormone replacement therapy (HRT); vaginal maturation index (VMI); vaginal atrophy; postmenopausal women; menopause;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Utian, WH N Amer Menopause Soc, 5900 landerbrook Dr,Suite 195, Mayfield Hts, OH 44124 USA N Amer Menopause Soc 5900 landerbrook Dr,Suite 195 MayfieldHts OH USA 44124
Citazione:
W.H. Utian et al., "Relief of vasomotor symptoms and vaginal atrophy with lower doses of conjugated equine estrogens and medroxyprogesterone acetate", FERT STERIL, 75(6), 2001, pp. 1065-1079

Abstract

Objective: To evaluate the efficacy of lower doses of conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA) for relieving vasomotor symptoms and vaginal atrophy. Design: A randomized, double-blind, placebo-controlled trial (the Women's Health, Osteoporosis, Progestin, Estrogen study). Setting: Study centers across the United States. Patient(s): Two thousand, six hundred, seventy-three healthy, postmenopausal women with an intact uterus, including an efficacy-evaluable population (n = 241 at baseline). Intervention(s): Patients received for 1 year (13 cycles; in milligrams per day) CEE, 0.625; CEE, 0.625 and MPA, 2.5; CEE, 0.45; CEE, 0.45 and MPA, 2.5; CEE, 0.45 and MPA, 1.5; CEE, 0.3; CEE, 0.3 and MPA, 1.5; or placebo. Main Outcome Measure(s): Number and severity of hot flushes and Papanicolaou smear with vaginal maturation index (VMI) to assess vaginal atrophy. Result(s): In the efficacy-evaluable population, reduction in vasomotor symptoms was similar with CEE of 0.625 mg/d and MPA of 2.5 mg/d (the most commonly prescribed doses) and all lower combination doses. CEE of 0.625 mg/d alleviated hot flushes more effectively than the lower doses of CEE alone. VMI improved in all active treatment groups. Conclusion(s): Lower doses of CEE plus MPA relieve vasomotor symptoms and vaginal atrophy as effectively as commonly prescribed doses. (Fertil Steril(R) 2001;75:1065-79. (C)2001 by American Society for Reproductive Medicine.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:46:32