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Titolo:
Predicting sensory events - The role of the cerebellum in motor learning
Autore:
Nixon, PD; Passingham, RE;
Indirizzi:
Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England Univ Oxford Oxford England OX1 3UD Expt Psychol, Oxford OX1 3UD, England
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 138, anno: 2001,
pagine: 251 - 257
SICI:
0014-4819(200105)138:2<251:PSE-TR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; GENERATED LIMB MOVEMENTS; VISUOMOTOR SEQUENCE; FRONTAL LOBES; ARM MOVEMENTS; STRIATUM; MONKEY; INACTIVATION; COGNITION; THALAMUS;
Keywords:
cerebellum; basal ganglia; sensory prediction; reaction-time task; primates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Nixon, PD Univ Oxford, Dept Expt Psychol, S Parks Rd, Oxford OX1 3UD, England Univ Oxford S Parks Rd Oxford England OX1 3UD OX1 3UD, England
Citazione:
P.D. Nixon e R.E. Passingham, "Predicting sensory events - The role of the cerebellum in motor learning", EXP BRAIN R, 138(2), 2001, pp. 251-257

Abstract

There is growing evidence that the cerebellum is involved in the implicit learning of movement sequences. On the serial reaction time (RT) task patients with cerebellar lesions fail to demonstrate normal decreases in RT and we have shown a similar effect in monkeys with bilateral cerebellar lesions. However, it is not clear if this impairment is unique to sequence learning or whether the cerebellum is also involved in the learning of discrete responses to predictable visual targets. We investigated this possibility in another group of monkeys with bilateral lesions of the cerebellum centred on the lateral nuclei. Three animals were pre-operatively trained to make rapid manual responses to a single target appearing on a touch-sensitive VDU screen. In one condition, a target could appear at any of three possible locations (spatially unpredictable). In a second condition the target always appeared in the same place (spatially predictable). A third condition was similar to the second except that the onset of the target was temporally predictable whereas in the previous conditions this parameter was randomized. Following the lesions, the RT savings earned on the conditions in which thecues were predictable were abolished. This was despite a lack of significant increase in movement times. The results im ply that the animals were either failing to predict the spatial location or time of presentation of the target, or that they were unable to use their prediction to improve their reaction times. The function of the cerebellum in motor sequence learning may therefore be part of a more general operation in learning to prepare responses to predictable sensory events.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:49:42