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Titolo:
Black tea extract, thearubigin fraction, counteracts the effect of tetanustoxin in mice
Autore:
Satoh, E; Ishii, T; Shimizu, Y; Sawamura, S; Nishimura, M;
Indirizzi:
Univ Obihiro, Sch Vet Med, Dept Pharmacol, Obihiro, Hokkaido 0808555, Japan Univ Obihiro Obihiro Hokkaido Japan 0808555 hiro, Hokkaido 0808555, Japan Univ Obihiro, Sch Vet Med, Cooperat Res Ctr, Obihiro, Hokkaido 0808555, Japan Univ Obihiro Obihiro Hokkaido Japan 0808555 hiro, Hokkaido 0808555, Japan Ito en Ltd, Tokyo 1510071, Japan Ito en Ltd Tokyo Japan 1510071Ito en Ltd, Tokyo 1510071, Japan
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 6, volume: 226, anno: 2001,
pagine: 577 - 580
SICI:
1535-3702(200106)226:6<577:BTETFC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BOTULINUM NEUROTOXIN; BINDING; TOXICITY;
Keywords:
tetanus toxin; thearubigin fraction; diaphragm; synaptosome; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Nishimura, M Univ Obihiro, Sch Vet Med, Dept Pharmacol, Obihiro, Hokkaido 0808555, Japan Univ Obihiro Obihiro Hokkaido Japan 0808555 o 0808555, Japan
Citazione:
E. Satoh et al., "Black tea extract, thearubigin fraction, counteracts the effect of tetanustoxin in mice", EXP BIOL ME, 226(6), 2001, pp. 577-580

Abstract

The aim of this study was to find an inactivating substance for tetanus toxin in natural foodstuff. Tetanus toxin (4 mug/ml) abolished indirect twitches in in vitro mouse phrenic nerve-diaphragm preparations within 2.5 hr. Hot water infusion of black tea mixed with tetanus toxin blocked the inhibitory effect of the toxin. Mixing the toxin with thearubigin fraction extracted from black tea infusion produced an identical result, Furthermore, thearubigin fraction mixed with the toxin protected against the in vivo paralytic effect of the toxin. Thearubigin fraction had no protective effect on other toxins, such as tetrodotoxin and saxitoxin. The specific binding of [I-125]tetanus toxin to rat cerebrocortical synaptosomes was inhibited by mixing iodinated toxin with thearubigin fraction. These results imply that thearubigin fraction counteracts the effect of tetanus toxin by binding with toxin, and also suggest that this fraction may be able to apply for prophylaxis of tetanus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:44:29